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merck millipore,默克密理博,07-1531,Anti-phospho-PFKFB2 (Ser466) Antibody
产品名称：Anti-phospho-PFKFB2 (Ser466) Antibody
产品型号：07-1531
Anti-phospho-PFKFB2 (Ser466) Antibody detects level of phospho-PFKFB2 (Ser466) & has been published & validated for use in WB, PIA.
merck millipore,默克密理博,07-1531,Anti-phospho-PFKFB2 (Ser466) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Pm, H, R, M, B, Xn WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1531 描述 Anti-phospho-PFKFB2 (Ser466) Antibody Alternate Names - Fructose-2,6-bisphosphatase
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
- 6PF-2-K/Fru-2,6-P2ase 2
- PFK/FBPase 2
- 6PF-2-K/Fru-2,6-P2ase heart-type isozyme
- 6-phosphofructo-2-kinase
背景信息 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) is an enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart (a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle) to regulate glycolysis and gluconeogensis. 产品信息 格式 Affinity Purified 控制 - Untreated and insulin-treated HEK293 cell lysates
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-phospho-PFKFB2 (Ser466) Antibody detects level of phospho-PFKFB2 (Ser466) & has been published & validated for use in WB, PIA. 主要应用 - Western Blotting
应用说明 Peptide Inihibition Analysis: A 1:500 dilution from a representative lot blocked PFKFB2 in PANC-1 cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human PFKFB2 phosphorylated at (Ser466). 表位 Phosphorylated Ser466 宿主 Rabbit 特异性 This antibody recognizes PFKFB2 phosphorylated at Ser466. 品种反应性 PrimateHumanRatMouseBovineXenopus Species Reactivity Note Demonstrated to react with Human.
Predicted to react with Rat, Mouse, Bovine, Xenopus, and Primate based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_006203
Entrez基因汇总 The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 基因符号 - PFKFB2
修改 - Phosphorylation
纯化方法 Affinity Purified UniProt编号 - O60825
UniProt汇总 FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate.
CATALYTIC ACTIVITY: Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
ENZYME REGULATION: Phosphorylation results in the activation of the kinase activity.
SUBUNIT STRUCTURE: Homodimer (By similarity).
TISSUE SPECIFICITY: Heart.
SEQUENCE SIMILARITIES: In the C-terminal section; belongs to the phosphoglycerate mutase family.产品使用声明 质量保证 Evaluated by Western Blot in Insulin untreated and treated Hek293 cell lysates.
Western Blot Analysis: A 1:500 dilution of this antibody detected PFKFB2 in 10 µg of untreated and insulin-treated HEK293 cell lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µL
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