merck millipore,默克密理愽
  • merck millipore,默克密理博,05-698,Anti-hSNF2h Antibody, clone 1B9/D12

  • merck millipore,默克密理博,05-698,Anti-hSNF2h Antibody, clone 1B9/D12

    产品名称：Anti-hSNF2h Antibody, clone 1B9/D12
    产品型号：05-698
    Anti-hSNF2h Antibody, clone 1B9/D12 is a high quality Mouse Monoclonal Antibody for the detection of hSNF2h & has been validated in IP, WB, ICC.

    merck millipore,默克密理博,05-698,Anti-hSNF2h Antibody, clone 1B9/D12

  • 产品介绍
  • merck millipore,默克密理博,05-698,Anti-hSNF2h Antibody, clone 1B9/D12

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-698
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-hSNF2h Antibody, clone 1B9/D12
    概述 The SNF2 family of proteins are ATP dependant chromatin remodeling enzymes. Anti-hSNF2, clone 1B9/D12 recognizes both hSNF2H and hSNF2L
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Anti-hSNF2h Antibody, clone 1B9/D12 is a high quality Mouse Monoclonal Antibody for the detection of hSNF2h & has been validated in IP, WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 Purified, full-length human SNF2h
    克隆 clone 1B9/D12
    宿主 Mouse
    特异性 SNF2h, aka SMARCA5 and SNF2L, aka SMARCA1
    同种型 IgG3
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    •  NM_003601.2
    Entrez基因汇总 The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
    基因符号
    • ISWI
    • SMARCA5
    • WCRF135
    • hISWI
    • hSNF2H
    • SNF2H
    • HSNF2H
    纯化方法 Protein A chromatography
    UniProt编号
    • O60264
    UniProt汇总 FUNCTION: SwissProt: O60264 # Possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin in vitro; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter.
    SIZE: 1052 amino acids; 121905 Da
    SUBUNIT: Catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. ACF/WCRF contains BAZ1A; CHRAC contains BAZ1A, CHRAC1, and POLE3; RSF contains RSF1; WICH contains BAZ1B. SMARCA5 is the catalytic subunit of the NoRC chromatin-remodeling complex, which also contains BAZ2A and of SMARCA5/cohesin/NuRD complexes. The BAZ2A subunit of NoRC also interacts with DNMT1, DNMT3B and HDAC1, which allows NoRC to actively suppress rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Ubiquitously expressed.DEVELOPMENTAL STAGE: Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy.
    SIMILARITY: SwissProt: O60264 ## Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. & Contains 1 helicase ATP-binding domain. & Contains 1 helicase C-terminal domain. & Contains 2 SANT domains.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on nuclear extract from HeLa cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-698,Anti-hSNF2h Antibody, clone 1B9/D12

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