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merck millipore,默克密理博,219377,Cathepsin K Inhibitor I - Calbiochem
产品名称：Cathepsin K Inhibitor I - Calbiochem
产品型号：219377
The Cathepsin K Inhibitor I controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
merck millipore,默克密理博,219377,Cathepsin K Inhibitor I - Calbiochem
- 产品介绍
重要规格表
经验配方 C₃₁H₄₂N₄O₇ 描述 概述 A cell-permeable, symmetrical bis(acylamino)ketone that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 22 nM). Shown to bind to cathepsin K and span both the S- and S′-subsites. A poor inhibitor of papain (Ki,app > 10 µM) but displays greater selectivity towards other proteases of the papain family (Ki,app = 340 nM, 890 nM, and 1.3 µM for cathepsin L, cathepsin S, and cathepsin B respectively). Inhibits trypsin and chymotrypsin activities only at higher concentrations (Ki,app ≥ 50 µM). 产品目录编号 219377 品牌系列 Calbiochem®
同义词 1,3-Bis(CBZ-Leu-NH)-2-propanone, 1,3-Bis(N-carbobenzoyloxy-L-leucyl)amino Acetone 参考 参考 Claveau, D., et al. 2000. Biochem. Pharmacol. 60, 759.
LaLonde, J.M., et al. 1999. Biochemistry 38, 862.
Yamashita, D.S., et al. 1997. J. Am. Chem. Soc. 119, 11351.产品信息 具有ATP竞争性 N 形式 Off-white lyophilized solid Hill配方 C₃₁H₄₂N₄O₇ 化学配方 C₃₁H₄₂N₄O₇ Molar Mass 582.7 肽序列 Cbz-Leu-NH-CH₂-CO-CH₂-NH-Leu-Cbz 可逆 Y 生物信息 主靶 cathepsin K 主靶Ki 22 nM against cathepsin K 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or MeOH 肽序列 Cbz-Leu-NH-CH₂-CO-CH₂-NH-Leu-Cbz 储存和货运信息 货运代码 Blue Ice Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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