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merck millipore,默克密理博,06-994,Anti-CAP (c-Cbl associated protein) Antibody
产品名称：Anti-CAP (c-Cbl associated protein) Antibody
产品型号：06-994
Anti-CAP (c-Cbl associated protein) Antibody detects level of CAP (c-Cbl associated protein) & has been published & validated for use in WB.
merck millipore,默克密理博,06-994,Anti-CAP (c-Cbl associated protein) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-994 品牌系列 Upstate
商名 - Upstate
描述 Anti-CAP (c-Cbl associated protein) Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-CAP (c-Cbl associated protein) Antibody detects level of CAP (c-Cbl associated protein) & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 192-206 (CEKRAKDDSRRVVKST) of human CAP (c-Cbl associated protein), also known as ponsin 宿主 Rabbit 特异性 CAP and two other isoforms or alternatively spliced variants at 125 and 53kDa; other splice variants that may be detected are at 75kDa and 45kDa 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_015385
基因符号 - CAP
- SORBS1
- SH3P12
- DKFZp586P1422
- DKFZP586P1422
- DKFZp451C066
- KIAA1296
- Ponsin
- SH3D5
- FLAF2
- sh3p12
- SORB1
- ponsin
- R85FL
- FLJ12406
纯化方法 Protein A chromatography UniProt编号 - Q9BX66
UniProt汇总 FUNCTION: SwissProt: Q9BX66 # Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
SIZE: 1292 amino acids; 142455 Da
SUBUNIT: Interacts with the long isoform of MLLT4/afadin and with VCL. MLLT4 and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/p125FAK and flotillin.
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions.TISSUE SPECIFICITY: Widely expressed with highest levels in heart and skeletal muscle.
PTM: O-glycosylated (By similarity).
SIMILARITY: SwissProt: Q9BX66 ## Contains 3 SH3 domains. & Contains 1 SoHo domain.产品使用声明 质量保证 routinely evaluated by immunoblot on a RIPA lysate prepared from a 3T3-L1 adipocytes 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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