merck millipore,默克密理愽
  • merck millipore,默克密理博,06-642,Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody,

  • merck millipore,默克密理博,06-642,Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody,

    产品名称：Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody,
    产品型号：06-642
    Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody, detects level of phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) & has been published & validated for use in IP & WB.

    merck millipore,默克密理博,06-642,Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody,

  • 产品介绍
  • merck millipore,默克密理博,06-642,Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody,

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBShAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-642
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody,
    产品信息
    格式 Affinity Purified
    演示 0.2M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody, detects level of phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) & has been published & validated for use in IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Synthetic peptide (CTGFLTEpYVAT) corresponding to residues 174-183 of human MAP Kinase
    宿主 Sheep
    特异性 phosphorylated Erk1 and Erk2
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002745, NM_002746
    Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
    基因符号
    • ERT1
    • MAPK1
    • p38
    • ERK
    • P42MAPK
    • ERK2
    • p40
    • PRKM1
    • p41mapk
    • PRKM2
    • MAPK2
    • p42-MAPK
    • p41
    • ERK-2
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity chromatography
    UniProt编号
    • P28482
    UniProt汇总 FUNCTION: SwissProt: P28482 # Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
    COFACTOR: Magnesium (By similarity).
    SIZE: 360 amino acids; 41390 Da
    SUBUNIT: Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine- kinase activity. Interacts with HSF4.
    DOMAIN: SwissProt: P28482 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    PTM: Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.
    SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates of NGF-stimulated PC-12 cells, mouse 3T3/A31 cells or human A431 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-642,Anti-phospho-MAP Kinase1/2 (Erk1/2) (Tyr180) Antibody,

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