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品种反应性 主要应用 宿主 格式 抗体类型 Pm, H, Chp WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1116 描述 Anti-IL-33R ST2 (IL1RL1) Antibody Alternate Names - Protein ST23
- interleukin 1 receptor-like 1
- interleukin-1 receptor-like 1
- growth stimulation-expressed
- homolog of mouse growth stimulation-expressed
- interleukin 1 receptor-related protein
背景信息 Interleukin-1 receptor-like 1 (IL-33R ST2) is a member of the interleukin-1 receptor family, and is comprised of three Ig-like C2-type domains and a single TIR domain. IL-33R ST2 functions as a receptor for IL-33, and, following phosphorylation with MAPKa/ERK2, MAPK3/ERK1, MAPK8 and/ore MAPK14, serves to recruit IRAK1, IRAk4, MYD88, and TRAF6. It is also thought to have a potential role in the function of helper T-cells. High expression has been reported in colon, kidney, lung, placenta, skeletal muscle, small intestines, and the stomach. Isoform A has been noted to be more prevalent in colon, lung, placenta, testis and stomach, while Isoform B has greater presence in brain, liver and kidney. 产品信息 格式 Affinity Purified 控制 - Human kidney tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-IL-33R ST2 (IL1RL1) Antibody is an antibody against IL-33R ST2 (IL1RL1) for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected IL-33R ST2 in normal human thymus tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the extracellular domain of human IL-33R ST2. 表位 Extracellular Domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the extracellular domain of IL-33R ST2. 品种反应性 PrimateHumanChimpanzee Species Reactivity Note Demonstrated to react with human.
Predicted to react with chimpanzee and primate based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_057316
Entrez基因汇总 The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]. 基因符号 - ST2V
- T1
- DER4
- IL1RL1
- ST2
- FIT1
- ST2L
纯化方法 Affinity Purified UniProt编号 - Q01638
UniProt汇总 FUNCTION: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
SUBUNIT STRUCTURE: Interacts with MYD88, IRAK1, IRAK4, and TRAF6.
SUBCELLULAR LOCATION: Isoform C: Cell membrane
Isoform B: Secreted Ref.10.
Cell membrane; Single-pass type I membrane protein
TISSUE SPECIFICTY: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Ref.10
SEQUENCE SIMILARITIES: Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.产品使用声明 质量保证 Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-33R ST2 in 10 µg of human kidney tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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