merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1952,Anti-SETDB2 Antibody, clone 5B7.2

  • merck millipore,默克密理博,05-1952,Anti-SETDB2 Antibody, clone 5B7.2

    产品名称：Anti-SETDB2 Antibody, clone 5B7.2
    产品型号：05-1952
    Use Anti-SETDB2 Antibody, clone 5B7.2 (mouse monoclonal antibody) validated in WB to detect SETDB2 also known as SET domain bifurcated 2, chronic lymphocytic leukemia deletion region 8, histone-lysine More>>

    merck millipore,默克密理博,05-1952,Anti-SETDB2 Antibody, clone 5B7.2

  • 产品介绍
  • merck millipore,默克密理博,05-1952,Anti-SETDB2 Antibody, clone 5B7.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1952
    描述 Anti-SETDB2 Antibody, clone 5B7.2
    Alternate Names
    • SET domain bifurcated 2
    • SET domain, bifurcated 2
    • chromosome 13 open reading frame 4
    • chronic lymphocytic leukemia deletion region 8
    • Lysine N-methyltransferase 1F
    • histone-lysine N-methyltransferase SETDB2
    • Chronic lymphocytic leukemia deletion region gene 8 protein
    背景信息 SET domain bifurcated 2 (SETDB2), also known as Histone-lysine N-methyltransferase SETDB2 is a ubiquitous, nuclear protein belonging to the histone-lysine methyltransferase family and is comprised of a MBD (Methyl-CpG-binding) domain, a pre-SET domain, and a SET domain. Data suggests that SETDB2 is a methyltransferase with specific activity against histones. Studies also suggest that it may be a key regulatory component in the development of dorsal organizer and left-right asymmetry during early embryonic development by downregulating fibroblast growth factor 8. Although expression of the protein is considered ubiquitous, high levels have been reported in heart, ovary and testis tissues.
    产品信息
    格式 Purified
    控制
    • A431 cell lysate
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 Use Anti-SETDB2 Antibody, clone 5B7.2 (mouse monoclonal antibody) validated in WB to detect SETDB2 also known as SET domain bifurcated 2, chronic lymphocytic leukemia deletion region 8, histone-lysine N-methyltransferase SETDB2.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Recombinant protein corresponding to human SETDB2.
    克隆 5B7.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgMκ
    品种反应性 HumanMouse
    Species Reactivity Note Demonstrated to react with mouse and human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001153780
    Entrez基因汇总 Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM].
    基因符号
    • CLLL8
    • SETDB2
    • CLLD8
    • KMT1F
    纯化方法 Ion Exchange
    UniProt编号
    • Q96T68
    UniProt汇总 FUNCTION: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

    CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    SUBCELLULAR LOCATION: Nucleus. Chromosome Probable

    TISSUE SPECIFICTY: Ubiquitous. Highest expression in heart, testis and ovary.

    SEQUENCE SIMILARITIES: Belongs to the histone-lysine methyltransferase family.

    Contains 1 MBD (methyl-CpG-binding) domain.

    Contains 1 pre-SET domain.

    Contains 1 SET domain.

    SEQUENCE CAUTION: The sequence CAH56265.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    The sequence CAI10818.2 differs from that shown. Reason: Erroneous gene model prediction.
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected SETDB2 on 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1952,Anti-SETDB2 Antibody, clone 5B7.2

上一件merck millipore产品：merck millipore,默克密理博,218735,Caspase Inhibitor II - CAS 147837-52-3 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,07-681,Anti-phospho-AMPK α (Thr172) Antibody


相关产品

merck millipore,默克密理博,DR1061,Anti-ENO1 Mouse mAb (8G8) merck millipore,默克密理博,DR1061,Anti-ENO1 Mouse mAb (8G8)

merck millipore,默克密理博,AB5112,Anti-Parkin Antibody, a.a. 305-323 merck millipore,默克密理博,AB5112,Anti-Parkin Antibody, a.a. 305-323

merck millipore,默克密理博,06-1116,Anti-IL-33R ST2 (IL1RL1) Antibody merck millipore,默克密理博,06-1116,Anti-IL-33R ST2 (IL1RL1) Antibody

merck millipore,默克密理博,292500,Diethylamine NONOate - CAS 56329-27-2 - Calbiochem merck millipore,默克密理博,292500,Diethylamine NONOate - CAS 56329-27-2 - Calbiochem

merck millipore,默克密理博,218735,Caspase Inhibitor II - CAS 147837-52-3 - Calbiochem merck millipore,默克密理博,218735,Caspase Inhibitor II - CAS 147837-52-3 - Calbiochem

merck millipore,默克密理博,07-681,Anti-phospho-AMPK α (Thr172) Antibody merck millipore,默克密理博,07-681,Anti-phospho-AMPK α (Thr172) Antibody

merck millipore,默克密理博,71242,pIEx™-5 DNA - Novagen merck millipore,默克密理博,71242,pIEx™-5 DNA - Novagen

merck millipore,默克密理博,521276,PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem merck millipore,默克密理博,521276,PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem

merck millipore,默克密理博,UFC801024,Amicon Ultra-4，PLGC Ultracel-PL 超滤膜，10 kDa merck millipore,默克密理博,UFC801024,Amicon Ultra-4，PLGC Ultracel-PL 超滤膜，10 kDa

merck millipore,默克密理博,219477,Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem merck millipore,默克密理博,219477,Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部