merck millipore,默克密理愽
  • merck millipore,默克密理博,521276,PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem

  • merck millipore,默克密理博,521276,PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem

    产品名称：PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem
    产品型号：521276
    The PDK1 Inhibitor II, also referenced under CAS 850717-64-5, controls the biological activity of PDK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat More>>

    merck millipore,默克密理博,521276,PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,521276,PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₄N₄O₂850717-64-5
    描述
    概述 A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDK1 inhibitor (IC50 = 6 nM) and effectively suppresses cellular Akt Thr308 phosphorylation level in PC-3 cultures (IC50 ≤1 µM), while affecting PKA (IC50 = 1.6 µM) and 7 other kinases (IC50 ≥600 nM) only at much higher concentrations. Its in vivo applicability is limited by a low aqueous solubility (2 µg/ml in PBS) and poor pharmacokinetics.
    产品目录编号 521276
    品牌系列 Calbiochem®
    同义词 2-Oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]indolin-5-yl]urea, BX-517
    参考
    参考 Islam, I., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3819.
    Islam, I., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3814.
    产品信息
    CAS号 850717-64-5
    形式 Dark brown solid
    Hill配方 C₁₅H₁₄N₄O₂
    化学配方 C₁₅H₁₄N₄O₂
    Molar Mass 282.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC (sum of two isomers)
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,521276,PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem

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