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品种反应性 主要应用 宿主 格式 抗体类型 H ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1097 描述 Anti-Jagged2 Antibody Alternate Names - Jagged2
- jagged 2
背景信息 Jagged 2 is a notch ligand belonging to the Notch gene family and is a necessary component for embryonic development. Notch is the receptor for Delta and Jagged ligands, which cause proteolysis of notch to liberate the intracellular domain. It is expressed in the heart, placenta and skeletal muscle and some expression is found in the pancreas, brain, lung, liver and kidney. Mutations in Jagged2 may be associated with multiple myeloma. 产品信息 格式 Affinity Purified 控制 - Ductal carcinoma in situ tissue
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-Jagged2 Antibody is validated for use in IH(P), ELISA for the detection of Jagged2. 主要应用 - ELISA
应用说明 Specificity confirmed with direct ELISA. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Jagged2. 表位 Cytoplasmic 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Jagged2 at the cytoplasmic domain. 品种反应性 Human Species Reactivity Note Demonstrated to react with human. Other homologies: Rat (83% sequence homology). Mouse (75% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002217
Entrez基因汇总 The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. 基因符号 - JAG2
- HJ2
- SER2
纯化方法 Affinity purified UniProt编号 - Q9Y219
UniProt汇总 FUNCTION: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICTY: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.
SEQUENCE SIMILARITIES: Contains 1 DSL domain.
Contains 16 EGF-like domains.
Contains 1 VWFC domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry in ductal carcinoma in situ tissue.
Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Jagged2 in ductal carcinoma in situ tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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