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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE204 描述 Anti-Ash1L Antibody Alternate Names - Lysine N-methyltransferase 2H
- Histone-lysine N-methyltransferase ASH1L
- EC 2.1.1.43
- ASH1-like protein
- huASH1
- Absent small and homeotic disks protein 1 homolog
背景信息 Ash1L, also known as Histone-lysine N-methyltransferase ASH1L, or ASH1-like protein (huASH1), Absent small and homeotic disks protein 1 homolog, or Lysine N-methyltransferase 2H, and encoded by the gene ASH1L/KIAA1420/KMT2H, is a histone methyltransferase that specifically methylates Lys-36 of histone H3 (H3K36me). ASH1L is one of several H3K36-specific methyltransferases. Others include HYPB, NSD1 and NSD2 proteins. ASH1L's activity is regulated by many processes but one interesting one is the inhibition of ASH1L by the presence of ubiquitinated histone H2a (ubH2a). All of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1 and NSD2 appear to be inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a and Pr-Set7 are not affected by ubH2A. This finding helps to partially explain how and why particular histone H3 proteins get methylated while others do not and thus provide some insight into is the mechanisms involved in polycomb chromatin structure and its effects on gene expression or silencing. Ash1L is localized to the nucleus and tight junctions and is widely expressed. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Ash1L Antibody detects level of Ash1L & has been published & validated for use in Ash1L. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Ash1L. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Human. Predicted to react with Bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_060959
基因符号 - KMT2H
- ASH1L
- KIAA1420
纯化方法 Affinity purified UniProt编号 - Q9NR48
产品使用声明 质量保证 Evaluated by Western Blotting in HeLa nuclear extract.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Ash1L in 10 µg of HeLa nuclear extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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