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描述 产品目录编号 14-756M 品牌系列 Upstate
商名 - Upstate
描述 ACK1 Protein, active, 250 µg 概述 N-terminal GST-tagged recombinant, human ACK1, residues 1-389. Alternate Names - tyrosine kinase, non-receptor, 2
- p21cdc42Hs
- FLJ45547
- FLJ44758
- ACK
- TNK2
应用 应用 Active, N-terminal GST-tagged recombinant, human ACK1, residues 1-389. For use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Expressed by baculovirus in Sf21 insect cells. 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_005781.4
- NM_001010938.1
Entrez基因汇总 This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. 基因符号 - FLJ45547
- TNK2
- FLJ44758
- ACK1
- p21cdc42Hs
- ACK
- ACK-1
蛋白靶 ACK1 纯化方法 Glutathione-agarose 靶子系列 TK UniProt编号 - Q07912
UniProt汇总 FUNCTION: SwissProt: Q07912 # Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
COFACTOR: Magnesium.
SIZE: 1036 amino acids; 114327 Da
SUBUNIT: Interacts with CDC42. Interacts with activated CSPG4.
SUBCELLULAR LOCATION: Cell membrane (By similarity).
SIMILARITY: SwissProt: Q07912 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. & Contains 1 SH3 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 -70°C from date of shipment. 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-756) and in bulk (cat# 14-756-K).
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