merck millipore,默克密理博,345700,Ganciclovir - CAS 82410-32-0

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merck millipore,默克密理博,345700,Ganciclovir - CAS 82410-32-0 - Calbiochem
产品名称：Ganciclovir - CAS 82410-32-0 - Calbiochem
产品型号：345700
A nucleoside analog structurally related to Acyclovir.

merck millipore,默克密理博,345700,Ganciclovir - CAS 82410-32-0 - Calbiochem

产品介绍

merck millipore,默克密理博,345700,Ganciclovir - CAS 82410-32-0 - Calbiochem

重要规格表

经验配方	CAS号
C₉H₁₃N₅O₄	82410-32-0

描述
概述	A nucleoside analog structurally related to Acyclovir (Cat. No. 114798). Acts as a prodrug that is activated by phosphorylation. Has been used in the study of “suicide” gene therapy in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G₂/M checkpoint. Has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.
产品目录编号	345700
品牌系列	Calbiochem®
同义词	9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

参考
参考	Aghi, M., et al. 2000. J. Gene Med. 2, 148. Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569. Cannon, J.S., et al. 1999. J. Virol. 73, 4786. Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669. Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781. Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151. Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.

参考

Aghi, M., et al. 2000. J. Gene Med. 2, 148.
Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.

产品信息
CAS号	82410-32-0
具有ATP竞争性	N
形式	White solid
Hill配方	C₉H₁₃N₅O₄
化学配方	C₉H₁₃N₅O₄
Molar Mass	255.2
可逆	N
结构配方图像

生物信息
主靶	Acts as a prodrug that is activated by phosphorylation
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or H₂O

GHS安全信息
RTECS	MF8407000

安全信息
R相	R: 46-60-61 May cause heritable genetic damage. May impair fertility. May cause harm to the unborn child.
S相	S: 36/37/39-45-53 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	-20°C
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.