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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-920 品牌系列 Upstate
商名 - Upstate
描述 Anti-NR2B Antibody, clone BWJHL 产品信息 格式 Purified 应用 应用 Anti-NR2B Antibody, clone BWJHL detects level of NR2B & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST fusion protein corresponding to residues 934-1457 of rat NR2B. Clone BWJHL. 克隆 clone BWJHL 宿主 Mouse 特异性 NR2B 同种型 IgG 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_012574
Entrez基因汇总 N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. 基因符号 - hNR3
- GRIN2B
- Glutamate
- MGC142178
- MGC142180
- NR2B
- NMDAR2B
- NR3
纯化方法 Protein G purfied UniProt编号 - Q13224
UniProt汇总 FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
SIZE: 1484 amino acids; 166367 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.产品使用声明 质量保证 routinely evaluated by immunoblot on rat brain microsomal preparations (Catalog#12-144) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 stable 2 years at -20°C from date of shipment 包装信息 数量 100 µg
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