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  • merck millipore,默克密理博,CBL243,Anti-Glucose Transporter GLUT-4 Antibody

  • merck millipore,默克密理博,CBL243,Anti-Glucose Transporter GLUT-4 Antibody

    产品名称：Anti-Glucose Transporter GLUT-4 Antibody
    产品型号：CBL243
    This Anti-Glucose Transporter GLUT-4 Antibody is validated for use in IP, WB for the detection of Glucose Transporter GLUT-4.

    merck millipore,默克密理博,CBL243,Anti-Glucose Transporter GLUT-4 Antibody

  • 产品介绍
  • merck millipore,默克密理博,CBL243,Anti-Glucose Transporter GLUT-4 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 CBL243
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Glucose Transporter GLUT-4 Antibody
    产品信息
    格式 Affinity Purified
    控制
    • Positive Control: 3T3 L1 adipocyte membranes
    演示 Purified immunoglobulin in PBS with 0.01% sodium azide.
    应用
    应用 This Anti-Glucose Transporter GLUT-4 Antibody is validated for use in IP, WB for the detection of Glucose Transporter GLUT-4.
    主要应用
    • Western Blotting
    应用说明 Western blot analysis of GLUT-4 activity in adipose and muscle tissue (5μg/ml)

    Immunoprecipitation of GLUT-4 (5μg/ml)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Partially purified GLUT-4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Specific for human glucose transporter-4 from muscle and adipose tissue. The antisera does not cross-react with GLUT-1. The molecular weight of the glucose transporter precipitated by the serum is approximately 46 kDa.
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001042.2
    Entrez基因汇总 This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
    基因符号
    • GLUT4
    • SLC2A4
    • GLUT-4
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P14672
    UniProt汇总 FUNCTION: SwissProt: P14672 # Insulin-regulated facilitative glucose transporter.
    SIZE: 509 amino acids; 54787 Da
    SUBUNIT: Binds to DAXX.
    SUBCELLULAR LOCATION: Intracytoplasmic membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.
    TISSUE SPECIFICITY: Skeletal and cardiac muscles; brown and white fat.
    PTM: Sumoylated.
    DISEASE: SwissProt: P14672 # Defects in SLC2A4 may be a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. Defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM. The variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects.
    SIMILARITY: SwissProt: P14672 ## Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
    MISCELLANEOUS: Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation (By similarity).
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CBL243,Anti-Glucose Transporter GLUT-4 Antibody

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