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merck millipore,默克密理博,220320,Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem
产品名称：Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem
产品型号：220320
A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300.
merck millipore,默克密理博,220320,Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₃₁H₃₀N₆O₆S₄ 1403-36-7 描述 概述 A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain. 产品目录编号 220320 品牌系列 Calbiochem®
同义词 CS-1, CTM 参考 参考 Fujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
Kung, A.L., et al. 2004. Cancer Cell 6, 33.产品信息 CAS号 1403-36-7 形式 Off-white solid Hill配方 C₃₁H₃₀N₆O₆S₄ 化学配方 C₃₁H₃₀N₆O₆S₄ Molar Mass 710.9 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO GHS安全信息 RTECS FM3038000 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Toxic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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