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品种反应性 主要应用 宿主 格式 抗体类型 Mk, H, M, R IHC, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MABD171 描述 Anti-BMR2 Antibody, clone 3F6 Alternate Names - BMPR-II
- Bone morphogenetic protein receptor type-2BMP type-2 receptor
- BMPR-2
- Bone morphogenetic protein receptor type II
- BMP type II receptor
背景信息 BMPR2 a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-β superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. 产品信息 格式 Ascites 控制 - HeLa, A431, NIH/3T3, Cos7 and PC-12 cell lysates
演示 Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide. 应用 应用 Anti-BMR2 Antibody, clone 3F6 is a mouse monoclonal antibody, validated for use in western blotting, Immunofluorescence & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunofluorescence Analysis: A 1:200-1,000 dilution from a representative lot detected BMPR2 in Eca109 cells.
Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected BMPR2 in muscle tissue and kidney cancer tissue.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Purified recombinant fragment of human BMR2 expressed in E. Coli. 克隆 3F6 宿主 Mouse 同种型 IgG1 品种反应性 MonkeyHumanMouseRat 抗体类型 Monoclonal Antibody 基因符号 - BMPR2
- BMR2
- PPH1
- BMPR3
- BRK-3
- T-ALK
- BMPR-II
- FLJ41585
- FLJ76945
纯化方法 Unpurified 产品使用声明 质量保证 Evaluated by Western Blot in HeLa, A431, NIH/3T3, Cos7 and PC-12 cell lysates.
Western Blot Analysis: A 1:500-2,000 dilution of this antibody detected BMPR2 in HeLa, A431, NIH/3T3, Cos7 and PC-12 cell lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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