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  • merck millipore,默克密理博,AB5338P,Anti-Cocaine and Amphetamine Related Transcript Antibody

  • merck millipore,默克密理博,AB5338P,Anti-Cocaine and Amphetamine Related Transcript Antibody

    产品名称：Anti-Cocaine and Amphetamine Related Transcript Antibody
    产品型号：AB5338P
    This Anti-Cocaine & Amphetamine Related Transcript Antibody is validated for use in ELISA, WB, IH for the detection of Cocaine & Amphetamine Related Transcript.

    merck millipore,默克密理博,AB5338P,Anti-Cocaine and Amphetamine Related Transcript Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5338P,Anti-Cocaine and Amphetamine Related Transcript Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MIHC, ELISA, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5338P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cocaine and Amphetamine Related Transcript Antibody
    Alternate Names
    • CART/CARP
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA and 0.05% sodium azide.
    应用
    应用 This Anti-Cocaine & Amphetamine Related Transcript Antibody is validated for use in ELISA, WB, IH for the detection of Cocaine & Amphetamine Related Transcript.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Western Blotting
    应用说明 Western blotting: 1-10 μg/mL using ECL.

    Immunohistochemistry: 5-10 μg/mL It has been reported that the antibody will recognize CART in neurons (cell bodies) from the rat hypothalamic arcuate nucleus.

    ELISA: 1:10,000-1:50,000 using 50-100 ng control peptide (Catalog Number AG228) per well.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Mouse/rat CART peptide (55-102).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Cocaine- and Amphetamine Related Transcript (CART). CART has been found to control satiety modulating the actions of two key regulators of food intake, leptin and NPY. Starvation decreases CART levels in the arcuate nucleus (Kristensen et al. 1998). Obese animals have virtually no CART. CART inhibits both normal and starvation-induced feeding, and completely inhibits NPY-induced feeding. Immunoneutralization of CART by administration of anti-CART resulted into higher food intake suggesting that CART is an endogenous regulator of food intake.
    品种反应性 RatMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_004291.2
    Entrez基因汇总 CART appears to have roles in reward, feeding, and stress, and it has the functional properties of an endogenous psychostimulant (Kuhar et al., 2002 [PubMed 12147208]).[supplied by OMIM]
    基因符号
    • CART
    • CARTPT
    UniProt编号
    • Q16568
    UniProt汇总 FUNCTION: SwissProt: Q16568 # Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
    SIZE: 116 amino acids; 12829 Da
    SUBCELLULAR LOCATION: Secreted (Potential).
    TISSUE SPECIFICITY: Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.
    DISEASE:SwissProt: Q16568 # A defect in CART is associated with reduced resting energy expenditure and cosegregates with obesity phenotype.
    SIMILARITY: SwissProt: Q16568 ## Belongs to the CART family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB5338P,Anti-Cocaine and Amphetamine Related Transcript Antibody

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