merck millipore,默克密理博,AG796,Angiotensin Converting Enzyme, bovine

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Merck Millipore 默克密理愽

merck millipore,默克密理博,AG796,Angiotensin Converting Enzyme, bovine
产品名称：Angiotensin Converting Enzyme, bovine
产品型号：AG796

merck millipore,默克密理博,AG796,Angiotensin Converting Enzyme, bovine

主要应用	品种	Uni Prot编号
PC	Bovine	P12820

描述
产品目录编号	AG796
品牌系列	Chemicon®
商名	Chemicon
描述	Angiotensin Converting Enzyme, bovine
概述	ACE (kininase II, EC 3.4.15.1) is a zinc dipeptidyl carboxypeptidase (Kozlowski et al., 1992). ACE catalyses both angiotensin I transformation to angiotensis II (a potent vasopressor agent) and degradation of bradikinin, a vasodepressor. Thus, ACE appears to play a key role in regulating vascular tone and remodeling as well as in the development of atherosclerotic lesions. Increasing evidence asuggests that ACE plays an important role in vascular pathology. Recent studies show two new functions for this important enzyme: 1) ACE enhances presentation of endogenous antigens (such as HIV gp160-derived peptide p18) to MHC class I-restricted T-lymphocytes (Kozlowski et al., 1992); 2) amino-terminal domain of ACE efficiently cleaves hemoregulatory tetrapeptide N-Ac-Ser-Asp-Lys-Pro (Reiger et al., 1993; Rousseau et al., 1995) which is involved in the control of haemopoetic stem cell proliferation (the amount of this peptide greatly decreases in patients undergoing cancer chemotherapy) (Bogden, 1991).
Alternate Names	Peptidase P ACE CD143 DCP1 Peptidyl-dipeptidase A

应用
主要应用	Positive Control
应用说明	1) As a reference in SDS-PAGE and Western blotting in combination with anti-ACE MABs (MAB3500 and MAB3502). For Western with anti-ACE monoclonal antibodies load 20 ng/lane. 2) As a reference antigen for immunoprecipitation of ACE from various tissue samples. 3) For enzymatic studies (substrate specificity, enzyme kinetics, etc.). Optimal working concentrations must be determined by the end user.

生物信息
浓缩	See lot specific Datasheet for specific concentration and activity.
纯度	>95% as determined by SDS-PAGE.
来源	Isolated from bovine lung membrane by lisinopril-affinity chromatography (ref 5).
品种	Bovine
特异活性	One unit produces 1 mmole of hippuric acid or His-Leu from Hippuril-His-Leu per min in 0.1 M phosphate buffer-300 mM NaCl, pH 8.3 at 37&deg:C. <br /><br />pH-OPTIMUM: pH 7.5-8.5
基因符号	DCP1 ACE
UniProt编号	P12820

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots for up to 12 months. Maintain at 4°C for up to one month. A decrease in activity may occur within prolonged storage at 4°C.

包装信息
数量	1 units

merck millipore,默克密理博,AG796,Angiotensin Converting Enzyme, bovine

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