merck millipore,默克密理博,233183,Clodronate, Disodium Salt - CAS 22560-50-5

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Merck Millipore 默克密理愽

merck millipore,默克密理博,233183,Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem

经验配方	CAS号
CH₂Cl₂O₆P₂Na₂ • 4H₂O	22560-50-5

描述
概述	A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).
产品目录编号	233183
品牌系列	Calbiochem®
同义词	Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

参考
参考	Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255. Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708. Smith, R., et al. 1971. Lancet 1, 945. Fleisch, H., et al. 1969. Nature 223, 211.

生物信息
主靶	Osteoclast-mediated bone resorption
主靶IC₅₀	100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells
纯度	≥97% by titration

理化信息
细胞可渗透	N
溶解度	H₂O

GHS安全信息
RTECS	SZ7640700

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,233183,Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem

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