merck millipore,默克密理愽
  • merck millipore,默克密理博,05-760,Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9

  • merck millipore,默克密理博,05-760,Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9

    产品名称：Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9
    产品型号：05-760
    Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9 is an antibody against Fibrinogen γ' for use in ELISA & WB.

    merck millipore,默克密理博,05-760,Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9

  • 产品介绍
  • merck millipore,默克密理博,05-760,Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-760
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%.
    应用
    应用 Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9 is an antibody against Fibrinogen γ' for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    生物信息
    免疫原品种 peptide corresponding to amino acids 434-453 (VRPEHPAETEYDSLYPEDDL) of human fibrinogenγ
    克隆 2.G2.H9
    宿主 Mouse
    特异性 fibrinogenγ
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000509
    Entrez基因汇总 The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
    基因符号
    • ORFNames=PRO2061
    • FGG
    纯化方法 Protein G purfied
    UniProt编号
    • P02679
    UniProt汇总 FUNCTION: SwissProt: P02679 # Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    SIZE: 453 amino acids; 51512 Da
    SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).
    SUBCELLULAR LOCATION: Secreted.
    DOMAIN: SwissProt: P02679 A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
    PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon- (gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. & Sulfation of C-terminal tyrosines increases affinity for thrombin.DISEASE:SwissProt: P02679 # Defects in FGG are a cause of thrombophilia. & Defects in FGG are a cause of congenital afibrinogenemia [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
    SIMILARITY: Contains 1 fibrinogen C-terminal domain.
    MISCELLANEOUS: The gamma-chain carries the main binding site for the platelet receptor.
    产品使用声明
    质量保证 human plasma from normal donors.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-760,Anti-Fibrinogen γ' Antibody, CT, clone 2.G2.H9

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