merck millipore,默克密理愽
  • merck millipore,默克密理博,489477,LSD1 Inhibitor II, S2101 - Calbiochem

  • merck millipore,默克密理博,489477,LSD1 Inhibitor II, S2101 - Calbiochem

    产品名称：LSD1 Inhibitor II, S2101 - Calbiochem
    产品型号：489477
    The LSD1 Inhibitor II, S2101 controls the biological activity of LSD1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

    merck millipore,默克密理博,489477,LSD1 Inhibitor II, S2101 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,489477,LSD1 Inhibitor II, S2101 - Calbiochem

    重要规格表

    经验配方
    C₁₆H₁₆ClF₂NO
    描述
    概述 A cell-permeable, 2-PCPA derivative that elicits mechanism-based inhibition against LSD1 (IC50 = 0.99 µM, KI = 0.61 µM, and kinact/KI = 4560 M-1S-1), and displays much lower inhibition activity toward MAO-B (KI = 17 µM, kinact/KI = 18 M-1S-1) and MAO-A (KI = 110 µM, kinact/KI = 60 M-1S-1), with higher potency and selectivity compared with those of 2-PCPA (Cat. No. 616431) (IC50 = 184 µM, KI = 100 µM, kinact/KI = 58 M-1S-1 for LSD1, and K I = 26 µM, kinact/KI = 271 M-1S-1 for MAO-B, and K I = 5 µM,
    kinact/KI = 1050 M-1S-1 for MAO-A). The inhibition of LSD1 is further confirmed in a cell-based assay, the treatment of HEK293T human cells with S2101 results in a dose-dependent increase in the level of H3K4me2, and about 50-fold stronger inhibition compared with that of 2-PCPA.
    产品目录编号 489477
    品牌系列 Calbiochem®
    同义词 LSD Inhibitor II, S2101, BHC110 Inhibitor II, Histone Lysine Demethylase Inhibitor IV, KDM1 Inhibitor II, MOA Inhibitor II
    参考
    参考 Mimasu, S., et al. 2010. Biochemistry 49, 6494.
    产品信息
    形式 White solid
    Hill配方 C₁₆H₁₆ClF₂NO
    化学配方 C₁₆H₁₆ClF₂NO
    Molar Mass 311.75
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,489477,LSD1 Inhibitor II, S2101 - Calbiochem

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