merck millipore,默克密理愽
  • merck millipore,默克密理博,05-756,Anti-Calsenilin/DREAM Antibody, clone 40A5

  • merck millipore,默克密理博,05-756,Anti-Calsenilin/DREAM Antibody, clone 40A5

    产品名称：Anti-Calsenilin/DREAM Antibody, clone 40A5
    产品型号：05-756
    Detect Calsenilin/DREAM using this Anti-Calsenilin/DREAM Antibody, clone 40A5 validated for use in IP & WB.

    merck millipore,默克密理博,05-756,Anti-Calsenilin/DREAM Antibody, clone 40A5

  • 产品介绍
  • merck millipore,默克密理博,05-756,Anti-Calsenilin/DREAM Antibody, clone 40A5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-756
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Calsenilin/DREAM Antibody, clone 40A5
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect Calsenilin/DREAM using this Anti-Calsenilin/DREAM Antibody, clone 40A5 validated for use in IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Full length GST fusion protein of human Calsenilin/DREAM
    克隆 clone 40A5
    宿主 Mouse
    特异性 Calsenilin/DREAM
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_013434
    Entrez基因汇总 This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
    基因符号
    • KCHIP3
    • KCNIP3
    • MGC18289
    • KChIP3
    • DREAM
    • CSEN
    • calsenilin
    • Calsenilin
    纯化方法 Ascites
    UniProt编号
    • Q9Y2W7
    UniProt汇总 FUNCTION: SwissProt: Q9Y2W7 # May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
    SIZE: 256 amino acids; 29231 Da
    SUBUNIT: Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Component of heteromultimeric potassium channels. Interacts with KCND2 and KCND3 (By similarity). Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1.
    SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Lipid-anchor (By similarity). Endoplasmic reticulum. Golgi apparatus. Nucleus (Probable). Note=Also membrane-bound, associated with the plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi.
    TISSUE SPECIFICITY: Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
    PTM: Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity). & Proteolytically cleaved by caspase-3.
    SIMILARITY: SwissProt: Q9Y2W7 ## Belongs to the recoverin family. & Contains 4 EF-hand domains.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA homogenate from human Alzheimers diseased brain
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µL

    merck millipore,默克密理博,05-756,Anti-Calsenilin/DREAM Antibody, clone 40A5

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