- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M FC R Purified Monoclonal Antibody 描述 产品目录编号 04-1518 描述 Anti-PD-1 Antibody, clone RMP1-14 Alternate Names - CD279
- Programmed cell death protein 1
- Protein PD-1
- mPD-1
背景信息 PD-1 (Programmed cell death protein 1, CD279) is a single-pass type 1 transmembrane protein that contains an Ig-like V-type domain on the extracellular region and a tyrosine-based motif on the intracellular region. PD-1 functions as an immunoreceptor that is activated by the PD-L1 ligand. PD-1 is expressed on the surface of activated T- and B-cells. It plays an inhibitory role on T-cell function, and may block T-cell—mediated events such as the proliferation of lymphocytes and the secretion of cytokines. PD-1 may therefore negatively regulate immune responses, and disruption of PD-1 function may affect tolerance. 产品信息 格式 Purified 控制 - BHK cells
演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Detect PD-1 using this Anti-PD-1 Antibody, clone RMP1-14 validated for use in Flow Cytometry. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Recombinant protein corresponding to mouse PD-1. 表位 Extracellular Domain 克隆 RMP1-14 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 0 同种型 IgG2aκ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with Mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_032824
基因符号 - Pd1
- Pdcd1
纯化方法 Protein G purified UniProt编号 - Q02242
UniProt汇总 FUNCTION: Inhibitory cell surface receptor involved in the regulation of T cell function during immunity and tolerance. Upon ligand binding, inhibits T cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).
SUBUNIT STRUCTURE: Monomer.
SUBCELLULAR LOCATION Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Thymus.
DEVELOPMENTAL STAGE: Induced at programmed cell death.
SEQUENCE SIMILARITIES: Contains 1 Ig-like V-type (immunoglobulin-like) domain.产品使用声明 质量保证 Evaluated by Flow Cytometry in BHK cells.
Flow Cytometry Analysis: 0.5 µg of this antibody detected PD-1 in BHK cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,07-1334,Anti-JunD Antibody
下一件merck millipore产品：merck millipore,默克密理博,04-234,Anti-NFĸB p50 Antibody, clone E381, rabbit monoclonal
相关产品
merck millipore,默克密理博,0500-0240,Guava Express Software
merck millipore,默克密理博,MABD187,Anti-Smad7, clone EPR622, Rabbit Monoclonal Antibody
merck millipore,默克密理博,05-756,Anti-Calsenilin/DREAM Antibody, clone 40A5
merck millipore,默克密理博,324833,EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem
merck millipore,默克密理博,07-1334,Anti-JunD Antibody
merck millipore,默克密理博,04-234,Anti-NFĸB p50 Antibody, clone E381, rabbit monoclonal
merck millipore,默克密理博,MAB5280,Anti-Tyrosine Hydroxylase Antibody, clone 2/40/15
merck millipore,默克密理博,AB5320,Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody
merck millipore,默克密理博,69741,pET-21b(+) DNA - Novagen
merck millipore,默克密理博,MAB5296,Anti-Oxytocin Antibody, clone 4G11