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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB M Purified Monoclonal Antibody 描述 产品目录编号 05-522 品牌系列 Upstate
商名 - Upstate
描述 Anti-SRC-1 Antibody, clone 1135 Alternate Names - MGC129720
- NCoA-1
- SRC1
- SRC-1
- KAT13A
- RIP160
- MGC129719
背景信息 Steroid Receptor Coactivator-1 (SRC-1) is a member of a gene family that functions in the full transcriptional activation of the steroid hormone receptor superfamily and contains intrinsic histone acetyltransferase activity. SRC-1 has a molecular weight of 160 kDa and has a basic helix-loop-helix (bHLH)-PAS domain. SRC-1 is also known as Nuclear receptor coactivator 1 (NCoA-1). 产品信息 格式 Purified 控制 - Cos-1 cell lysate
演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-SRC-1 Antibody, clone 1135 is a Mouse Monoclonal Antibody for the detection of SRC-1 & has been validated in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST fusion-protein containing amino acids 477-947 of human SRC-1 (Steroid Receptor Coactivator-1) 克隆 clone 1135 宿主 Mouse 特异性 SRC-1 isoforms 同种型 IgG1κ 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003743 and others
Entrez基因汇总 This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. 基因符号 - NCOA1
纯化方法 Protein G chromatography UniProt编号 - Q15788
UniProt汇总 SIZE: 536 amino acids; 59835 Da
SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.产品使用声明 质量保证 routinely evaluated by immunoblot on Cos-1 cell lysate or HeLa Nuclear Extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µg
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