merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1564,Anti-mTOR Antibody, clone 21A12.2

  • merck millipore,默克密理博,05-1564,Anti-mTOR Antibody, clone 21A12.2

    产品名称：Anti-mTOR Antibody, clone 21A12.2
    产品型号：05-1564
    Detect mTOR using this Anti-mTOR Antibody, clone 21A12.2 validated for use in WB & IC.

    merck millipore,默克密理博,05-1564,Anti-mTOR Antibody, clone 21A12.2

  • 产品介绍
  • merck millipore,默克密理博,05-1564,Anti-mTOR Antibody, clone 21A12.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1564
    描述 Anti-mTOR Antibody, clone 21A12.2
    Alternate Names
    • rapamycin-insensitive companion of mTOR
    • TORC2-specific protein AVO3
    背景信息 mTOR (Mammalian Target of Rapamycin, FRAP, RAPT or RAFT) is a large 289 kDa Ser/Thr protein kinase that regulates cell cycle progression, cell growth, protein synthesis, ribosome biogenesis, and autophagy. mTOR is an evolutionarily conserved member of the Phosphoinositol Kinase-related Kinase (PIKK) family whose activity is regulated by phosphorylation on Ser2448 by Akt in response to insulin or muscle activity. mTOR is the central component of two multimeric kinase complexes consisting of mTOR and numerous other mTOR binding proteins. These two multimeric protein complexes are designated mTORC1 and mTORC2. mTORC1 consists of at least mTOR, Raptor, and GL. mTORC1 is known to play a central role in insulin signaling, which is crucial in maintaining metabolic homeostasis. The other mTOR complex, mTORC2, is made up of at least mTOR, Rictor, GL, Sin1, Protor 1 and 2. TORC2 affects cell proliferation and survival primarily by phosphorylating the hydrophobic motif of Akt on Ser473. TORC2 complex is also known to effect cytoskeletal organization and migration by exerting its effects through Rac, Rho, and PKC. Defects in both mTOR complexes are associated with a variety of diseases, including cancer and diabetes.
    产品信息
    格式 Purified
    控制
    • HEK293 cell lysates
    演示 Purified mouse monoclonal in buffer containing 0.1 M Tris-Glycine (pH7.4), 150 mM NaCl, with 0.05% sodium azide.
    应用
    应用 Detect mTOR using this Anti-mTOR Antibody, clone 21A12.2 validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Confocal Immunofluorescent Immunocytochemistry:
    生物信息
    免疫原品种 Full-length human mTOR
    克隆 clone 21A12.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody only detects mTOR.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Human. Other species to be tested.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_004949.1
    基因符号
    • pianissimo
    • DKFZp686B11164
    • KIAA1999
    • MGC39830
    • mAVO3
    纯化方法 Protein G purfied
    UniProt编号
    • Q6R327
    UniProt汇总 FUNCTION: Plays an essential role in embryonic growth and development By similarity. Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.

    SUBUNIT STRUCTURE: Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2.

    SEQUENCE CAUTION: The sequence CAH18135.1 differs from that shown. Reason: Frameshift at position 251.

    产品使用声明
    质量保证 Evaluated by Western Blotting on HEK293 cell lysates.

    Western Blotting Analysis: 1:1,000 - 2,000 dilution of this antibody was used to detect mTOR in HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1564,Anti-mTOR Antibody, clone 21A12.2

上一件merck millipore产品：merck millipore,默克密理博,17-10121,ChIPAb+ Acetyl-Histone H4 (Lys12) - ChIP Validated Antibody and Primer Set, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,MAB3705,Anti-STAT3 Antibody, phospho (Ser727), clone 6E4


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