merck millipore,默克密理愽
  • merck millipore,默克密理博,234501,Compound 401 - CAS 168425-64-7 - Calbiochem

  • merck millipore,默克密理博,234501,Compound 401 - CAS 168425-64-7 - Calbiochem

    产品名称：Compound 401 - CAS 168425-64-7 - Calbiochem
    产品型号：234501
    A cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC₅₀ = 280 nM) with ~19-fold selectivity over mTOR (IC₅₀ = 5.3 µM).

    merck millipore,默克密理博,234501,Compound 401 - CAS 168425-64-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,234501,Compound 401 - CAS 168425-64-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₅N₃O₂168425-64-7
    描述
    概述 A cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.
    产品目录编号 234501
    品牌系列 Calbiochem®
    同义词 2-(Morpholin-1-yl)pyrimido[2,1-a]isoquinolin-4-one
    参考
    参考 Ballou, L.M., et al. 2007. J. Biol. Chem. 282, 24463.
    Griffin, R.J., et al. 2005. J. Med. Chem. 48, 569.
    产品信息
    CAS号 168425-64-7
    形式 Beige solid
    Hill配方 C₁₆H₁₅N₃O₂
    化学配方 C₁₆H₁₅N₃O₂
    Molar Mass 281.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,234501,Compound 401 - CAS 168425-64-7 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,17-10121,ChIPAb+ Acetyl-Histone H4 (Lys12) - ChIP Validated Antibody and Primer Set, rabbit monoclonal


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