merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3705,Anti-STAT3 Antibody, phospho (Ser727), clone 6E4

  • merck millipore,默克密理博,MAB3705,Anti-STAT3 Antibody, phospho (Ser727), clone 6E4

    产品名称：Anti-STAT3 Antibody, phospho (Ser727), clone 6E4
    产品型号：MAB3705
    Use Anti-STAT3 Antibody, phospho (Ser727), clone 6E4 (Mouse Monoclonal Antibody) validated in IP, WB, ICC, IHC(P) to detect STAT3 also known as Signal Transducer & Activator of Transcription 3.

    merck millipore,默克密理博,MAB3705,Anti-STAT3 Antibody, phospho (Ser727), clone 6E4

  • 产品介绍
  • merck millipore,默克密理博,MAB3705,Anti-STAT3 Antibody, phospho (Ser727), clone 6E4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3705
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-STAT3 Antibody, phospho (Ser727), clone 6E4
    Alternate Names
    • Acute-phase Response Factor
    • Signal Transducer and Activator of Transcription 3
    产品信息
    格式 Purified
    演示 Liquid in 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, with 50% glycerol and less than 0.02% sodium azide.
    应用
    应用 Use Anti-STAT3 Antibody, phospho (Ser727), clone 6E4 (Mouse Monoclonal Antibody) validated in IP, WB, ICC, IHC(P) to detect STAT3 also known as Signal Transducer & Activator of Transcription 3.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western blotting: 1:1,000 (for best results, incubate membrane with diluted antibody in 5% nonfat dry milk, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight)

    Immunoprecipitation 1:50

    Immunohistochemistry (Paraffin) 1:100

    Immunocytochemistry (IF) 1:50

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser727 of mouse Stat3.
    表位 phospho-specific (Ser727)
    克隆 6E4
    宿主 Mouse
    特异性 Recognizes Stat3 when phosphorylated at Serine 727. It does not appreciably cross-react with the corresponding phosphorylated serines of other Stat proteins. This antibody does not react with nonphosphorylated Stat3 or with Stat3 phosphorylated at other sites.
    同种型 IgG2b
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_213662.1
    • NM_003150.3
    • NM_139276.2
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
    基因符号
    • MGC16063
    • STAT3
    • APRF
    • FLJ20882
    修改
    • Phosphorylation
    UniProt编号
    • P40763
    UniProt汇总 FUNCTION: SwissProt: P40763 # Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
    SIZE: 770 amino acids; 88068 Da
    SUBUNIT: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
    TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    PTM: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.
    DISEASE: "SwissProt: P40763 # Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures."
    SIMILARITY: SwissProt: P40763 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
    MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20ºC for up to 12 months from date of receipt. DO NOT ALIQUOT.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB3705,Anti-STAT3 Antibody, phospho (Ser727), clone 6E4

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下一件merck millipore产品：merck millipore,默克密理博,14-346,CHK1 Protein, active, 10 µg


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