merck millipore,默克密理愽
  • merck millipore,默克密理博,14-483,PKCγ Protein, active, 10 µg

  • merck millipore,默克密理博,14-483,PKCγ Protein, active, 10 µg

    产品名称：PKCγ Protein, active, 10 µg
    产品型号：14-483
    Active, recombinant, full-length human PKCγ, containing N-terminal His6 tag. For use in Kinase Assays.

    merck millipore,默克密理博,14-483,PKCγ Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-483,PKCγ Protein, active, 10 µg

    描述
    产品目录编号 14-483
    品牌系列 Upstate
    商名
    • Upstate
    描述 PKCγ Protein, active, 10 µg
    概述 Recombinant, full-length human PKCγ, containing N-terminal His6 tag

    PKC Lipid activator (Catalog # 20-133) is required for use.
    应用
    应用 Active, recombinant, full-length human PKCγ, containing N-terminal His6 tag. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human PKCγ expressed by baculovirus in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002739.3
    Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
    基因符号
    • PKCC
    • PRKCG
    • SCA14
    • MGC57564
    • PKC-gamma
    • PKCG
    蛋白靶 PKCγ
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • P05129
    UniProt汇总 FUNCTION: SwissProt: P05129 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
    COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
    SIZE: 697 amino acids; 78448 Da
    SUBUNIT: Interacts with CDCP1.
    DISEASE: SwissProt: P05129 # Defects in PRKCG are the cause of spinocerebellar ataxia 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.
    SIMILARITY: SwissProt: P05129 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of Histone H1
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-483M when ordering the 250 µg size.

    merck millipore,默克密理博,14-483,PKCγ Protein, active, 10 µg

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