merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB158F,Milli-Mark™ Anti-Caspase-2 -FITC Antibody, clone 10C6

  • merck millipore,默克密理博,FCMAB158F,Milli-Mark™ Anti-Caspase-2 -FITC Antibody, clone 10C6

    产品名称：Milli-Mark™ Anti-Caspase-2 -FITC Antibody, clone 10C6
    产品型号：FCMAB158F
    Milli-Mark Anti-Caspase-2 -FITC Antibody, clone 10C6 is an antibody against Caspase-2 for use in FC.

    merck millipore,默克密理博,FCMAB158F,Milli-Mark™ Anti-Caspase-2 -FITC Antibody, clone 10C6

  • 产品介绍
  • merck millipore,默克密理博,FCMAB158F,Milli-Mark™ Anti-Caspase-2 -FITC Antibody, clone 10C6

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCRFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB158F
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-Caspase-2 -FITC Antibody, clone 10C6
    背景信息 Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

    Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi.
    产品信息
    格式 FITC
    控制
    • MCF-7 cells.
    演示 Purified Rat monoclonal IgG2a conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Milli-Mark Anti-Caspase-2 -FITC Antibody, clone 10C6 is an antibody against Caspase-2 for use in FC.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Raised against the P19 subunit of recombinant human Caspase-2 protein.
    克隆 10C6
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    特异性 Antibody recognizes human Caspase-2 (ICH-1, Nedd-2).
    同种型 IgG2a
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human. Unconjugated antibody Cat. No. MAB3501 is known to react with Canine, Mouse, and Monkey.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_116764.2
    Entrez基因汇总 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
    基因符号
    • CASP2
    • NEDD2
    • ICH1
    • NEDD-2
    • ICH-1L/1S
    • CASP-2
    • ICH-1L
    • EC 3.4.22.55 [Contains: Caspase-2 subunit p18
    • Caspase-2 subunit p13
    • Caspase-2 subunit p12].
    纯化方法 Protein G purfied
    UniProt编号
    • P42575
    UniProt汇总 FUNCTION: SwissProt: P42575 # Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

    SIZE: 452 amino acids; 50685 Da

    SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.

    TISSUE SPECIFICITY: Expressed in larger amounts in the embryonic lung, liver and kidney than in the heart and brain. In the adults higher level expression is seen in the placenta, lung, kidney, pancreas than in the heart, brain, liver and skeletal muscle.

    PTM: The mature protease can process its own propeptide, but not that of other caspases.

    SIMILARITY: SwissProt: P42575 ## Belongs to the peptidase C14 family. & Contains 1 CARD domain.
    产品使用声明
    质量保证 Evaluated by flow cytometry using MCF-7 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB158F,Milli-Mark™ Anti-Caspase-2 -FITC Antibody, clone 10C6

上一件merck millipore产品：merck millipore,默克密理博,MAB8582-KC,Mouse Anti-RSV Fusion Protein, clone 102-10B (KC)
下一件merck millipore产品：merck millipore,默克密理博,AB3260-200UL,Anti-Endothelin Receptor A Antibody, a.a. 413-426 rET-A, CT


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