merck millipore,默克密理博,05-1466,Anti-FOXA1 Antibody, clone 2F83

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merck millipore,默克密理博,05-1466,Anti-FOXA1 Antibody, clone 2F83
产品名称：Anti-FOXA1 Antibody, clone 2F83
产品型号：05-1466
Use Anti-FOXA1 Antibody, clone 2F83 (Mouse Monoclonal Antibody) validated in WB, ICC, IHC(P) to detect FOXA1 also known as Forkhead box protein A1, hepatocyte nuclear factor 3 alpha.

merck millipore,默克密理博,05-1466,Anti-FOXA1 Antibody, clone 2F83

产品介绍

merck millipore,默克密理博,05-1466,Anti-FOXA1 Antibody, clone 2F83

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	ICC, WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	05-1466
描述	Anti-FOXA1 Antibody, clone 2F83
Alternate Names	hepatocyte nuclear factor 3, alpha Forkhead box protein A1 forkhead box A1
背景信息	FOXA1 (HNF3A, Hepatocyte nuclear factor 3-alpha) is member of the Forkhead family of winged-helix transcription factors. It is known to be involved in the development and differentiation of several organs including liver, kidney, pancreas, lung, prostate and mammary gland (Lupien, 2008). High expression of FOXA1 is often seen in tumors arising from both the prostate and breast where it is believed to interact with either the androgen receptor or estrogen receptor α, in each of the tumor type respectively (Lupien, 2008). In the case of ER, FOXA1 has gained notice because of its interactions with the cis-regulatory regions in heterochromatin and because it enhances the interaction of ER with chromatin (Badve, 2007).

产品信息
格式	Purified
演示	Purified mouse monoclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Use Anti-FOXA1 Antibody, clone 2F83 (Mouse Monoclonal Antibody) validated in WB, ICC, IHC(P) to detect FOXA1 also known as Forkhead box protein A1, hepatocyte nuclear factor 3 alpha.
主要应用	Immunocytochemistry Western Blotting
应用说明	Immunohistochemisty: Independent labs have verified this clone to work in paraffin-embedded IHC (IH(P)) of various mouse tissues including both embryonic and adult brain, adult digestive tract, adult respiratory tract, and adult urinary tract. Staining was performed using the antibody at a 1:2,000 dilution, but dilutions and conditions must be user optimized.

生物信息
免疫原品种	Recombinant human GST-FOXA1 protein encompassing amino acids 7-86.
表位	N-terminus
克隆	2F83
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This antibody detects human FOXA1 (HNF3α).
同种型	IgG1κ
品种反应性	MouseHuman
Species Reactivity Note	Human and Mouse. Other species have not been tested.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_937987
Entrez基因汇总	This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. [provided by RefSeq]
基因符号	TCF3A HNF-3-alpha HNF-3A HNF3A
纯化方法	Protein G purfied
UniProt编号	P55317
UniProt汇总	FUNCTION: Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. SUBCELLULAR LOCATION: Nucleus. SEQUENCE SIMILARITIES: Contains 1 fork-head DNA-binding domain.

产品使用声明
质量保证	Evaluated by western blot on HeLa nuclear extracts. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect FOXA1 in HeLa nuclear extract.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8ºC from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,05-1466,Anti-FOXA1 Antibody, clone 2F83

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