merck millipore,默克密理愽
  • merck millipore,默克密理博,475730,MRP1 Inhibitor II, Reversan - Calbiochem

  • merck millipore,默克密理博,475730,MRP1 Inhibitor II, Reversan - Calbiochem

    产品名称：MRP1 Inhibitor II, Reversan - Calbiochem
    产品型号：475730
    The MRP1 Inhibitor II, Reversan controls the biological activity of MRP1. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,475730,MRP1 Inhibitor II, Reversan - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475730,MRP1 Inhibitor II, Reversan - Calbiochem

    重要规格表

    经验配方
    C₂₆H₂₇N₅O₂
    描述
    概述 A cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
    产品目录编号 475730
    品牌系列 Calbiochem®
    同义词 Multidrug Resistance Protein 1 Inhibitor, Reversan
    参考
    参考 Burkhart, C.A., et al. 2009. Cancer Res. 69, 6573.
    产品信息
    形式 Pale yellow solid
    Hill配方 C₂₆H₂₇N₅O₂
    化学配方 C₂₆H₂₇N₅O₂
    Molar Mass 442.0
    结构配方图像
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,475730,MRP1 Inhibitor II, Reversan - Calbiochem

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