merck millipore,默克密理愽
  • merck millipore,默克密理博,04-970,Anti-Osteopontin Antibody, clone 6B6.2

  • merck millipore,默克密理博,04-970,Anti-Osteopontin Antibody, clone 6B6.2

    产品名称：Anti-Osteopontin Antibody, clone 6B6.2
    产品型号：04-970
    Anti-Osteopontin Antibody, clone 6B6.2 detects level of Osteopontin & has been published & validated for use in WB.

    merck millipore,默克密理博,04-970,Anti-Osteopontin Antibody, clone 6B6.2

  • 产品介绍
  • merck millipore,默克密理博,04-970,Anti-Osteopontin Antibody, clone 6B6.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-970
    描述 Anti-Osteopontin Antibody, clone 6B6.2
    Alternate Names
    • osteopontin
    • Bone sialoprotein 1
    • SPP1/CALPHA1 fusion
    • Urinary stone protein
    • bone sialoprotein I
    • osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
    • secreted phosphoprotein 1
    • secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
    • secreted phosphoprotein-1 (osteopontin, bone sialoprotein)
    • Uropontin
    背景信息 Osteopontin is a single-chain polypeptide. It is highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell attachment/signaling. Expression of osteopontin in a variety of tissues indicates a multiplicity of functions that involve one or more of these conserved motifs. While the lack of a clear phenotype in osteopontin "knockout" mice has not established a definitive role for osteopontin in any tissue, recent studies have provided some novel and intriguing insights into the versatility of this enigmatic protein in diverse biological events, including developmental processes, wound healing, immunological responses, tumorigenesis, bone resorption, and calcification. The ability of osteopontin to stimulate cell activity through multiple receptors linked to several interactive signaling pathways can account for much of the functional diversity.
    产品信息
    格式 Purified
    控制
    • Human serum lysate
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 Anti-Osteopontin Antibody, clone 6B6.2 detects level of Osteopontin & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis: 0.5 µg/mL from a representative lot detected Osteopontin on 10 µg of mouse kidney lysate.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human Osteopontin.
    表位 C-terminus
    克隆 6B6.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes Osteopontin at the C-terminus.
    同种型 IgMκ
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000573
    基因符号
    • SPP-1
    • BNSP
    • BSPI
    • ETA-1
    • Nephropontin
    • OPN
    纯化方法 Ion Exchange
    UniProt编号
    • P10451
    UniProt汇总 FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.

    Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).

    SUBUNIT STRUCTURE: Ligand for integrin alpha-V/beta-3.

    SUBCELLULAR LOCATION: Secreted.

    PTM: Extensively phosphorylated on clustered serine residues.

    N- and O-glycosylated.

    DISEASE: This protein plays a principal role in urinary stone formation as the stone matrix.

    SEQUENCE SIMILARITY: Belongs to the osteopontin family.
    产品使用声明
    质量保证 Evaluated by Western Blot in human serum lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Osteopontin on 10 µg of human serum lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-970,Anti-Osteopontin Antibody, clone 6B6.2

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