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merck millipore,默克密理博,438187,InSolution™ Lovastatin, Sodium Salt - Calbiochem
产品名称：InSolution™ Lovastatin, Sodium Salt - Calbiochem
产品型号：438187
Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.
merck millipore,默克密理博,438187,InSolution™ Lovastatin, Sodium Salt - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₄H₃₇O₆ • Na 描述 概述 Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. 产品目录编号 438187 品牌系列 Calbiochem®
参考 参考 Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.产品信息 形式 Liquid 配方 A 10 mM (5 mg/1.13 ml) solution of Lovastatin, Sodium Salt (Cat. No. 438186) in H₂O. Hill配方 C₂₄H₃₇O₆ • Na 化学配方 C₂₄H₃₇O₆ • Na Molar Mass 444.5 可逆 Y 结构配方图像 生物信息 主靶 HMG-CoA reductase 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 安全信息 S相 S: 24/25
Avoid contact with skin and eyes.储存和货运信息 货运代码 Dry Ice Only
毒性 Harmful
储存 ≤ -70°C
避光 Protect from light
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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