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merck millipore,默克密理博,MAB8879,Anti-Cdk4 Antibody, clone DCS-35
产品名称：Anti-Cdk4 Antibody, clone DCS-35
产品型号：MAB8879
Detect Cdk4 with Anti-Cdk4 Antibody, clone DCS-35 (Mouse Monoclonal Antibody), that has been shown to work in IF, IP, EA, WB & IHC.
merck millipore,默克密理博,MAB8879,Anti-Cdk4 Antibody, clone DCS-35
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M, Po IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB8879 Replaces MABE548 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cdk4 Antibody, clone DCS-35 背景信息 The prototype of the cdk family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid containing 10 mM PBS, pH 7.4 with 0.2% BSA and 0.09% sodium azide. 应用 应用 Detect Cdk4 with Anti-Cdk4 Antibody, clone DCS-35 (Mouse Monoclonal Antibody), that has been shown to work in IF, IP, EA, WB & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunofluorescence
Immunoprecipitation: excellent for coprecipitation of D-type cyclins bound to cdk4.
Western Blotting: 2-4 ug/mL
Kinase Assay
The prototype of the cdk family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Raised against purified recombinant cdk4 protein. 克隆 DCS-35 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes a 34 kDa protein identified as p34 or cyclin-dependent kinase 4 (cdk4). It shows no cross-reaction with other cdks. 同种型 IgG1κ 品种反应性 RatHumanMousePig 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000075.2
Entrez基因汇总 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. 基因符号 - EC 2.7.11.22
- CDK4
- PSK-J3
- CMM3
- MGC14458
UniProt编号 - P11802
UniProt汇总 FUNCTION: SwissProt: P11802 # Probably involved in the control of the cell cycle.
SIZE: 303 amino acids; 33730 Da
SUBUNIT: Forms a stable complex with D-type G1 cyclins. Interacts with SEI1 and ZNF655/VIK.
DISEASE: SwissProt: P11802 # CDK4 mutations are involved in tumor formation. & Defects in CDK4 are the cause of cutaneous malignant melanoma 3 (CMM3) [MIM:609048, 155600]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a preexisting benign nevus, which occurs most often in the skin but also may involve other sites.
SIMILARITY: SwissProt: P11802 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain liquid material at 2-8°C for up to 24 months. 包装信息 数量 50 µg
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