merck millipore,默克密理博,506168,p53 Activator VII, STIMA-1 - CAS 91634-12-7

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Merck Millipore 默克密理愽

merck millipore,默克密理博,506168,p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem

经验配方	CAS号
C₁₀H₈N₂O	91634-12-7

描述
概述	A cell-permeable styrylquinazoline compound that preferentially induces apoptotic death of mutant p53-harboring H1299-His175 and Saos-2-His273 tumor cells (IC₅₀ = 3.4 and 4.9 µM, respectively), while exhibiting much reduced potency towards p53-null (IC₅₀ = 9.6, 11.4, and 14.7 µM against H1299, Saos-2, and HCT116, respectively) or wild-type p53-expressing (IC₅₀ = 13.2 and 20.3 µM against HCT116 and HDF, respectively) cells. STIMA-1 is demonstrated to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.
产品目录编号	506168
品牌系列	Calbiochem®
同义词	2-Vinyl-1H-quinazolin-4-one, SH group Targeting and Induction of Massive Apoptosis

参考
参考	Zache, N., et al. 2008. Mol. Oncol. 2, 70.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at -20°C. Prepare fresh as required.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,506168,p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem

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