merck millipore,默克密理博,04-479,Anti-SREBP-2 Antibody, clone 2545

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merck millipore,默克密理博,04-479,Anti-SREBP-2 Antibody, clone 2545
产品名称：Anti-SREBP-2 Antibody, clone 2545
产品型号：04-479
Use Anti-SREBP-2 Antibody, clone 2545 (Mouse Monoclonal Antibody) validated in ELISA, WB to detect SREBP-2 also known as sterol regulatory element binding transcription factor 2.

merck millipore,默克密理博,04-479,Anti-SREBP-2 Antibody, clone 2545

产品介绍

merck millipore,默克密理博,04-479,Anti-SREBP-2 Antibody, clone 2545

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB, ELISA	M	Ascites	Monoclonal Antibody

描述
产品目录编号	04-479
品牌系列	Upstate
商名	Upstate
描述	Anti-SREBP-2 Antibody, clone 2545
Alternate Names	SREBP2, sterol regulatory element binding transcription factor 2 SREBP2

产品信息
格式	Ascites
演示	200 μL of mouse ascites of monoclonal IgG1 with 0.1% sodium azide.

应用
应用	Use Anti-SREBP-2 Antibody, clone 2545 (Mouse Monoclonal Antibody) validated in ELISA, WB to detect SREBP-2 also known as sterol regulatory element binding transcription factor 2.
主要应用	Western Blotting ELISA

生物信息
免疫原品种	Recombinant GST-tagged human SREBP-2 protein encompassing amino acids 48-403.
克隆	Clone 2545
宿主	Mouse
特异性	Reacts with both the precursor and mature forms of SREBP-2,
同种型	IgG1
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_004599.2
Entrez基因汇总	This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
基因符号	SREBP2 SREBF2 OTTHUMP00000028740 SREBP-2
UniProt编号	Q12772
UniProt汇总	FUNCTION: SwissProt: Q12772 # Transcriptional activator that binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. SIZE: 1141 amino acids; 123688 Da SUBUNIT: Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. TISSUE SPECIFICITY: Ubiquitously expressed in adult and fetal tissues. PTM: Under sterol-depleted conditions, SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage occurs within the luminal loop and is directly regulated by sterols. The second cleavage by site-2 protease occurs within the first transmembrane stretch and liberates the soluble transcription factor. Cleavage by the cysteine proteases, caspase- 3 and caspase-7, is induced during apoptosis, independent of sterol levels. SIMILARITY: SwissProt: Q12772 ## Contains 1 basic helix-loop-helix (bHLH) domain. MISCELLANEOUS: SREBPs have to be in a complex with the cleavage- activating protein (SCAP) to move to the Golgi and be cleaved by site-1 protease.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.