merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN281,Anti-Numb Antibody, clone 6G10.1

  • merck millipore,默克密理博,MABN281,Anti-Numb Antibody, clone 6G10.1

    产品名称：Anti-Numb Antibody, clone 6G10.1
    产品型号：MABN281
    Detect Numb using this Anti-Numb Antibody, clone 6G10.1 validated for use in WB & IC.

    merck millipore,默克密理博,MABN281,Anti-Numb Antibody, clone 6G10.1

  • 产品介绍
  • merck millipore,默克密理博,MABN281,Anti-Numb Antibody, clone 6G10.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN281
    描述 Anti-Numb Antibody, clone 6G10.1
    Alternate Names
    • S171
    • Protein numb homolog
    • h-Numb
    背景信息 Numb plays a key role in neurogenesis and in cell fate decisions. It maintains self-renewal properties in neural progenitor cells, which are also called radial glial cells (RGCs). It functions through inhibition of Notch signaling. Additionally, it is suggested to mediate local repair in brain ventricular wall damage.
    产品信息
    格式 Purified
    控制
    • A431 cell lysate
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 Detect Numb using this Anti-Numb Antibody, clone 6G10.1 validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Numb in HeLa and A431 cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Numb isoforms 1 and 2.
    克隆 6G10.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes Numb isoforms 1 and 2.
    同种型 IgMκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001005743
    Entrez基因汇总 The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • NUMB
    纯化方法 Purified by ion exchange chromatography
    UniProt编号
    • P49757
    UniProt汇总 FUNCTION: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

    SUBUNIT STRUCTURE: Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.

    SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Numb in 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABN281,Anti-Numb Antibody, clone 6G10.1

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