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描述 产品目录编号 14-544M 品牌系列 Upstate
商名 - Upstate
描述 PAR-1Bα Protein, active, 250 µg 概述 N-terminal His6-tagged, recombinant, full-length, human PAR-1B alpha 应用 应用 Active, N-terminal His6-tagged, recombinant, full-length, human PAR-1B alpha, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in SF21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_017490.2
- NM_001039468.1
- NM_001039469.1
- NM_004954.3
Entrez基因汇总 EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed. 基因符号 - PAR-1
- MARK2
- MGC99619
- EMK1
蛋白靶 PAR-1Ba 纯化方法 Ni2+/NTA-agarose 靶子系列 CAMK UniProt编号 - Q7KZI7
UniProt汇总 FUNCTION: SwissProt: Q7KZI7 # Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
COFACTOR: Magnesium.
SIZE: 788 amino acids; 87911 Da
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Note=Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.
TISSUE SPECIFICITY: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
SIMILARITY: SwissProt: Q7KZI7 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily. & Contains 1 KA1 (kinase-associated) domain. & Contains 1 protein kinase domain. & Contains 1 UBA domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of CHKtide 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-544) and in bulk (cat# 14-544-K).
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