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merck millipore,默克密理博,645890,Trio N-Terminal RhoGEF Domain Inhibitor, ITX3 - CAS 347323-96-0 - Calbiochem
产品名称：Trio N-Terminal RhoGEF Domain Inhibitor, ITX3 - CAS 347323-96-0 - Calbiochem
产品型号：645890
The Trio N-Terminal RhoGEF Domain Inhibitor, ITX3, also referenced under CAS 347323-96-0, controls the biological activity of Trio N-Terminal RhoGEF Domain. This small molecule/inhibitor is primarily More>>
merck millipore,默克密理博,645890,Trio N-Terminal RhoGEF Domain Inhibitor, ITX3 - CAS 347323-96-0 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,645890,Trio N-Terminal RhoGEF Domain Inhibitor, ITX3 - CAS 347323-96-0 - Calbiochem
重要规格表
经验配方 CAS号 C₂₂H₁₇N₃OS 347323-96-0 描述 概述 A cell-permeable thiazolo-benzimidazolone compound that inhibits Trio N-terminal RhoGEF domain- (TrioN) mediated RhoG activation (IC50 = 76 µM) and effectively reduces cellular Rac activation (by 80% with 50 µM ITX3) caused by TrioN, but not GEF337 (RhoA GEF), Tiam1 (Rac GEF), or Vav2 (Rac1/RhoA/Cdc42 GEF), overexpression in HEK293T cells. Culture treatment of ITX at 100 µM is shown to reduce NGF-induced neurite outgrowth of rat PC12 pheochromocytoma cells by 50% and block the formation of multinucleated myotubes by 78% in C2C12 mouse myoblasts cultures induced for differentiation, while the differentiation-associated Myogenin and Troponin T expressions in Trio knock-down C2C12 cells are not affected by ITX at the same concentration. 产品目录编号 645890 品牌系列 Calbiochem®
同义词 (2E)-(-2-((2,5-Dimethyl-1-phenyl-pyrrol-3-yl)methylene)thiazolo[3,2-a]benzimidazol-1-one, Inhibitor of Ttrio eXchange 3 参考 参考 Bouquier, N., et al. 2009. Chem. Biol. 16, 657. 产品信息 CAS号 347323-96-0 形式 Yellow solid Hill配方 C₂₂H₁₇N₃OS 化学配方 C₂₂H₁₇N₃OS Molar Mass 371.5 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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