merck millipore,默克密理博,04-412,Anti-Raf-1 Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-412,Anti-Raf-1 Antibody, rabbit monoclonal
产品名称：Anti-Raf-1 Antibody, rabbit monoclonal
产品型号：04-412
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Raf-1 Antibody, Rabbit is validated for us More>>

merck millipore,默克密理博,04-412,Anti-Raf-1 Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-412,Anti-Raf-1 Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-412
品牌系列	Upstate
商名	Upstate
描述	Anti-Raf-1 Antibody, rabbit monoclonal
Alternate Names	RAF1, CRAF, c-Raf, v-raf-1 murine leukemia viral oncogene homolog 1 RAF1 CRAF c-Raf

产品信息
格式	Purified
演示	100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Raf-1 Antibody, Rabbit is validated for use in IF, IH(P), IP, WB for the detection of Raf-1.
主要应用	Western Blotting
应用说明	Suggested Dilutions: Immunoblot Analysis: 1:500 Immunoprecipitation: 1:100 Immunohistochemistry (PE): 1:50 - 1:100 Immunfluorescence Staining: 1:50 - 1:100

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the central region of human Raf-1.
宿主	Rabbit
特异性	Recognizes Raf-1.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_002880.2
Entrez基因汇总	Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. [Contributed text]
基因符号	C-RAF RAF1 cRaf Raf-1 c-Raf RAF CRAF
UniProt编号	P04049
UniProt汇总	FUNCTION: SwissProt: P04049 # Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3. COFACTOR: Binds 2 zinc ions per subunit. SIZE: 648 amino acids; 73052 Da SUBUNIT: Interacts with Ras proteins. The interaction with Ras is antagonized by RIN1. Weakly interacts with RIT1 (By similarity). Interacts with STK3, which inhibits its pro-apoptotic activity. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY:SwissProt: P04049 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. & Contains 1 RBD (Ras-binding) domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.