merck millipore,默克密理博,04-1128,Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, rabbit monoclonal

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merck millipore,默克密理博,04-1128,Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, rabbit monoclonal
产品名称：Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, rabbit monoclonal
产品型号：04-1128
Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, Rabbit detects level of Casein Kinase II (beta subunit) & has been published & validated for use in WB, FC, IH(P) & IC.

merck millipore,默克密理博,04-1128,Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1128,Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	ICC, WB, FC	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1128
描述	Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, rabbit monoclonal
Alternate Names	casein kinase 2, beta polypeptide CK II beta Casein kinase II beta subunit alternative name: G5a, phosvitin
背景信息	Unlike most serine/threonine kinases, Casein Kinases (CKs) are not activated by specific stimuli, but are essentially constitutively active. CK1 autophosphorylates, causing inactivation, and protein phosphatases reactivate the kinase. The substrates of CKs are numerous, but their function is less clear, perhaps due to the absence of obvious regulation. CK1 isoforms are thought to be involved in the response to DNA damage, while CK2 levels are elevated in many types of cancer.

产品信息
格式	Unpurified
控制	K562 cell lysate
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl containing 40% Glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BSA.

应用
应用	Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, Rabbit detects level of Casein Kinase II (beta subunit) & has been published & validated for use in WB, FC, IH(P) & IC.
主要应用	Immunocytochemistry Western Blotting Flow Cytometry
应用说明	Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected Casein Kinase II (beta subunit) in human ovary carcinoma tissue. Immunocytochemistry Analysis: A 1:100-250 dilution from a previous lot detected Casein Kinase II (beta subunit) in HeLa cells. Flow Cytometry: A 1:20 dilution of a previous lot was used in flow cytometry.

生物信息
免疫原品种	Synthetic peptide corresponding to residues near the C-terminus of human Casein Kinase II (beta subunit).
表位	C-terminus
克隆	EP1995Y
宿主	Rabbit
特异性	This antibody recognizes Casein Kinase II (beta subunit).
同种型	IgG
品种反应性	RatHumanMouse
Species Reactivity Note	Human, mouse, and rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001311.3
Entrez基因汇总	This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.
基因符号	phosvitin CK2B CK2N CSK2B G5A G5a MGC138222 MGC138224 OTTHUMP00000029060 OTTHUMP00000029063 OTTHUMP00000029064 Phosvitin
纯化方法	Unpurified
UniProt编号	P67870
UniProt汇总	FUNCTION: Participates in Wnt signaling By similarity. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. SUBUNIT STRUCTURE: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with TCTEX1D3 By similarity. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. PTM: Phosphorylated by alpha subunit. SEQEUNCE SIMILARITIES: Belongs to the casein kinase 2 subunit beta family.

产品使用声明
质量保证	Evaluated by Western Blot on K562 cell lysates. Western Blot Analysis: A 1:500-2,000 dilution of this antibody was used to detect Casein Kinase II (beta subunit) in K562 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.