merck millipore,默克密理博,SF-476,JAK3; Human, Cyanine 5, RNA Detection Probe,SmartFlare

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Merck Millipore 默克密理愽

Entrez Gene Number	Species Reactivity
NM_000215.3	H

描述
产品目录编号	SF-476
商名	SmartFlare
描述	JAK3; Human, Cyanine 5, RNA Detection Probe \| SmartFlare
Alternate Names	JAK-3 JAKL LJAK
背景信息	With SmartFlare™ RNA Detection probes, you can detect RNA in LIVE CELLS with ease. With just an overnight incubation of JAK3; Human, Cyanine 5, RNA Detection Probe you can detect the presence of JAK3 within your cells. JAKs are non-receptor tyrosine kinases which couple to cytokine receptors, and are activated by cytokines. JAK kinases (JAK1, JAK2, JAK3, Tyk2) have a kinase domain and a second, pseudokinase domain which is not enzymatically active. The principal effectors of JAKs are the STATs, which are direct activators of transcription, but JAKs also signal to the Ras-MAP Kinase pathway, and through Tec, to the PI3 Kinase pathway. JAK3 is required for signaling through cytokine receptors which share a common γ chain. JAK2 is required for signaling through a different subset of cytokine receptors, while JAK1 is essential for signaling from the IL-2, IL-6 and interferon receptors. The stress-activated protein kinase 1 (SAPK) family is also referred to as the jun N-terminal kinase family in light of the substrate preference of these serine/threonine kinases. In addition to regulating many biological processes including proliferation and apoptosis, the JNK/SAPK family has been implicated in many neurodegenerative diseases including Alzheimer disease, Parkinson's disease and Amyotrophic lateral sclerosis.

产品信息
格式	Cyanine 5
演示	Lyophilized

应用
应用	Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare JAK3, Human, Cyanine 5, you can detect JAK3 RNA levels within your cells.
主要应用	RNA Detection

产品使用声明
质量保证	SmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store at 2–8°C in lyophilized format ONLY. Room temperature is required for reconstituted product.

包装信息
数量	250 reactions

merck millipore,默克密理博,SF-476,JAK3; Human, Cyanine 5, RNA Detection Probe,SmartFlare

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