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  • merck millipore,默克密理博,ABT48,Anti-Vesicle protein sorting 35 (VPS35) Antibody

  • merck millipore,默克密理博,ABT48,Anti-Vesicle protein sorting 35 (VPS35) Antibody

    产品名称：Anti-Vesicle protein sorting 35 (VPS35) Antibody
    产品型号：ABT48
    Anti-Vesicle protein sorting 35 (VPS35) Antibody is an antibody against Vesicle protein sorting 35 (VPS35) for use in WB.

    merck millipore,默克密理博,ABT48,Anti-Vesicle protein sorting 35 (VPS35) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABT48,Anti-Vesicle protein sorting 35 (VPS35) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 ABT48
    描述 Anti-Vesicle protein sorting 35 (VPS35) Antibody
    Alternate Names
    • Vesicle protein sorting 35
    • vacuolar protein sorting 35 homolog (S. cerevisiae)
    • vacuolar protein sorting 35
    • Maternal-embryonic 3
    • vacuolar protein sorting 35 (yeast homolog)
    • vacuolar protein sorting 35 (yeast)
    背景信息 Vacuolar protein sorting-associated protein 35 (VPS35) is critical component found within the retromer complex. The retromer complex is comprised of several proteins and has been implicated in roles involving the Wnt signaling pathway, cell migration and adhesion, and polymeric immunoglobulin A transcytosis. VPS35 plays an essential role in the selection and trafficking of lysosomal enzyme receptors from endosomes to the Golgi. It is also a required component for the secretion of active Wnt. Expression of VPS35 is pervasive throughout all tissue. Highest levels of expression have been observed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, spleen, testis, and thymus.
    产品信息
    格式 Purified
    控制
    • A431 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
    应用
    应用 Anti-Vesicle protein sorting 35 (VPS35) Antibody is an antibody against Vesicle protein sorting 35 (VPS35) for use in WB.
    主要应用
    • Western Blotting
    应用说明 RNAi: A previous lot of antibody was used in siRNA knockdown experiments by an independent laboratory (Courtesy of Gomez, TS, Mayo Clinic, 2010).
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human VPS35.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_060676
    Entrez基因汇总 This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq].
    基因符号
    • hVPS35
    • VPS35
    • MEM3
    纯化方法 Protein G
    UniProt编号
    • Q96QK1
    UniProt汇总 FUNCTION: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).

    SUBUNIT STRUCTURE: Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS26A and VPS26B. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GOLPH3. Ref.3 Ref.12

    SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein.

    TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.

    SEQUENCE SIMILARITIES: Belongs to the VPS35 family.

    SEQUENCE CAUTION: The sequence AAG01989.1 differs from that shown. Reason: Erroneous initiation.

    The sequence BAA91137.1 differs from that shown. Reason: Erroneous initiation.

    The sequence BAB14626.1 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected VPS35 in 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABT48,Anti-Vesicle protein sorting 35 (VPS35) Antibody

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