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Replacement Information Replacement Information 07-1225 is a recommended replacement for AB4092 重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-1225 Replaces AB4092 商名 - Upstate
描述 Anti-PP5 Antibody Alternate Names - Protein phosphatase 5, catalytic subunit
- Protein phosphatase T
- Serine/Threonine phosphatase
- Serine/threonine-protein phosphatase 5
- Protein phosphatase 5
背景信息 Protein phosphatase 5 (PP5) is a novel human protein serine/threonine phosphatase of molecular weight of 58 kDa. It is made up of a C-terminal phosphatase catalytic domain and an N-terminal domain, which has four repeats of 34 amino acids, three of which are tandemly arranged. The phosphatase domain contains all of the invariant motifs of the PP1/PP2A/PP2B gene family. However, it is not closely related to any other known member of this family of phosphatases. Thus it makes up a new subfamily of phosphatases. PP5 expressed in bacteria has been shown to dephosphorylate serine residues in proteins and is more sensitive than PP1 to the tumor promoter okadaic acid. PP5 appears to be localized to the nucleus where it is thought to play a roll in the regulation of RNA biogenesis and mitosis as part of a signaling pathway regulating cell cycle progression. 产品信息 格式 Purified 控制 - Jurkat Cell Lysate, A549 and MCF-7 cell lysates.
演示 Purified rabbit polyclonal IgG in phosphate buffered saline with 0.08% sodium azide 应用 应用 Detect PP5 using this Anti-PP5 Antibody validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry(paraffin):
Representative images from a previous lot.
Optimal Staining of PP5 Polyclonal Antibody: Human Testis
生物信息 免疫原品种 Synthetic peptide derived from the human protein phosphatase 5 protein. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Protein Phosphatase 5 (PP5). 同种型 IgG 品种反应性 MouseHuman Species Reactivity Note Human and mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006247.2
基因符号 - EC 3.1.3.16
- PPP5C
- PPP5
- FLJ36922
- PP-T
- PP5
- PPT
UniProt编号 - P53041
UniProt汇总 FUNCTION: SwissProt: P53041 # May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
SIZE: 499 amino acids; 56879 Da
SUBUNIT: Interacts with CDC16 and CDC27.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. But also present in the cytoplasm.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: SwissProt: P53041 ## Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. & Contains 3 TPR repeats.产品使用声明 质量保证 Routinely evaluated by Western Blot on Jurkat lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PP-5 on 10 μg of Jurkat lysates
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,12-343,Acetyl-Histone H4 (Lys5) Peptide
下一件merck millipore产品：merck millipore,默克密理博,SF-1340,BRD3; Human, Cyanine 5 RNA Detection Probe,SmartFlare
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