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品种反应性 主要应用 宿主 格式 抗体类型 B, R, M WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABT84 描述 Anti-Aggrecan Antibody, clone 1-C-6 Alternate Names - CSPCP
- Aggrecan core protein
- Cartilage-specific proteoglycan core protein
背景信息 Aggregating chondroitin sulfate proteoglycan or aggrecan, is one of the most studied proteoglycans. Many individual monomers of aggrecan bind to hyaluronic acid to form an aggregate, the monomer is known as aggrecan. The aggregates are comprised of up to 100 monomers attached to a single chain of hyaluronic acid. The high content of negatively charged polysaccharide chains contributes to the osmotic swelling of cartilage and in combination with intact collagen fibers results in articular cartilage resistance to compressive forces and high tensile strength. Aggrecan is abundant in articular cartilage and compromises 10% of its dry weight. 产品信息 格式 Purified 控制 - Normal mouse cartilage and normal rat cartilage tissues
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Aggrecan Antibody, clone 1-C-6 is validated for use in IH, WB for the detection of Aggrecan. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western Blot Analysis: 1 µg/mL from a representative lot detected Aggrecan on 10 µg of A1D4 protein fraction from Bovine tissue. 生物信息 免疫原品种 Reduced and alkylated Aggrecan isolated from Swarm Rat Chondrosarcoma 克隆 1-C-6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 BovineRatMouse Species Reactivity Note Demonstrated to react with Rat, Mouse, and Bovine. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_071526
Entrez基因汇总 An extracellular matrix proteoglycan; cleaved by ADAMTS1 [RGD, Feb 2006]. 基因符号 - Agc1
- Acan
- Agc
纯化方法 Protein G purified UniProt编号 - P07897
UniProt汇总 FUNCTION: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
SUBUNIT STRUCTURE: Interacts with FBLN1 and COMP (By similarity).
SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix (By similarity).
DOMAIN: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides.
SEQUENCE SIMILARITIES: Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 4 Link domains.
Contains 1 Sushi (CCP/SCR) domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry in normal mouse cartilage and normal rat cartilage tissues.
Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Aggrecan in normal mouse cartilage and normal rat cartilage tissues.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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