merck millipore,默克密理愽
  • merck millipore,默克密理博,182705,AhR Antagonist - CAS 301326-22-7 - Calbiochem

  • merck millipore,默克密理博,182705,AhR Antagonist - CAS 301326-22-7 - Calbiochem

    产品名称：AhR Antagonist - CAS 301326-22-7 - Calbiochem
    产品型号：182705
    The AhR Antagonist, also referenced under CAS 301326-22-7, controls the biological activity of AhR.

    merck millipore,默克密理博,182705,AhR Antagonist - CAS 301326-22-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,182705,AhR Antagonist - CAS 301326-22-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₉N₅O301326-22-7
    描述
    概述 A cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cells in vitro (IC50 = 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in mice in vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 µM.
    产品目录编号 182705
    品牌系列 Calbiochem®
    同义词 2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4-o-tolyl-azophenyl)-amide, CH-223191
    参考
    参考 Kim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.
    产品信息
    CAS号 301326-22-7
    具有ATP竞争性 N
    形式 Orange-brown
    Hill配方 C₁₉H₁₉N₅O
    化学配方 C₁₉H₁₉N₅O
    Molar Mass 333.4
    可逆 N
    结构配方图像
    生物信息
    主靶 AhR (aryl hydrocarbon receptor)
    主靶IC50 30 nM in blocking TCDD-induced AhR transcription activity in HepG2 cells in vitro
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,182705,AhR Antagonist - CAS 301326-22-7 - Calbiochem

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