merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT78,Anti-mouse CD44 (H-CAM) Antibody, clone KM201

  • merck millipore,默克密理博,MABT78,Anti-mouse CD44 (H-CAM) Antibody, clone KM201

    产品名称：Anti-mouse CD44 (H-CAM) Antibody, clone KM201
    产品型号：MABT78
    Detect mouse CD44 (H-CAM) using this Anti-mouse CD44 (H-CAM) Antibody, clone KM201 validated for use in FC.

    merck millipore,默克密理博,MABT78,Anti-mouse CD44 (H-CAM) Antibody, clone KM201

  • 产品介绍
  • merck millipore,默克密理博,MABT78,Anti-mouse CD44 (H-CAM) Antibody, clone KM201

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MFCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT78
    Replaces CBL1308
    描述 Anti-mouse CD44 (H-CAM) Antibody, clone KM201
    Alternate Names
    • hematopoietic cell E- and L-selectin ligand
    • CD44 antigen (homing function and Indian blood group system)
    • CDw44 antigen
    • HCAM
    • H-CAM
    • HUTCH-1
    • Phagocytic glycoprotein I
    • Extracellular matrix receptor III
    • GP90 lymphocyte homing/adhesion receptor
    • Heparan sulfate proteoglycan
    • Hermes antigen
    • Hyaluronate receptor
    • Epican
    • antigen gp90 homing receptor
    • chondroitin sulfate proteoglycan 8
    背景信息 CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.
    产品信息
    格式 Purified
    控制
    • Mouse bone marrow cells
    演示 Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
    应用
    应用 Detect mouse CD44 (H-CAM) using this Anti-mouse CD44 (H-CAM) Antibody, clone KM201 validated for use in FC.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Mouse bone marrow-derived stromal cells
    表位 Near the hyaluronate binding domain
    克隆 KM201
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    特异性 The antibody recognizes CD44 near the hyaluronate binding domain.
    同种型 IgG1κ
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001034240
    基因符号
    • Pgp1
    • CD44
    • CD44R
    • CDW44
    • CDw44
    • CSPG8
    • ECMR-III
    • Epican
    • HCELL
    • HUTCH-I
    • IN
    • LHR
    • MC56
    • MDU2
    • MDU3
    • MIC4
    • MUTCH-I
    • PGP-1
    • PGP-I
    纯化方法 Protein G
    UniProt编号
    • P15379
    UniProt汇总 FUNCTION: Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    PTM: N-glycosylated By similarity.

    O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated (By similarity).

    Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708 (By similarity).

    POLYMORPHISM: Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1).

    SEQUENCE SIMILARITIES: Contains 1 Link domain.
    产品使用声明
    质量保证 Evaluated by Flow Cytometry in mouse bone marrow cells.

    Flow Cytometry Analysis: 0.1 µg of this antibody detected CD44 in mouse bone marrow cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABT78,Anti-mouse CD44 (H-CAM) Antibody, clone KM201

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