merck millipore,默克密理博,124011,Akt Inhibitor IV - CAS 681281-88-9

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Merck Millipore 默克密理愽

merck millipore,默克密理博,124011,Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem

经验配方	CAS号
C₃₁H₂₇IN₄S	681281-88-9

描述
概述	A cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 625 nM) and cell proliferation (IC₅₀ <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available.
产品目录编号	124011
品牌系列	Calbiochem®

参考
参考	Kau, T.R., et al. 2003. Cancer Cell 4, 463. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

生物信息
主靶	Akt
主靶IC₅₀	625 nM in blocking Akt-mediated FOXO1a nuclear export; < 1.25 µM in blocking Akt-mediated cell proliferation in 786-O cells
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,124011,Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem

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