merck millipore,默克密理愽
  • merck millipore,默克密理博,506156,p38 MAP Kinase Inhibitor V - CAS 271576-77-3 - Calbiochem

  • merck millipore,默克密理博,506156,p38 MAP Kinase Inhibitor V - CAS 271576-77-3 - Calbiochem

    产品名称：p38 MAP Kinase Inhibitor V - CAS 271576-77-3 - Calbiochem
    产品型号：506156
    The p38 MAP Kinase Inhibitor V, also referenced under CAS 271576-77-3, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosp More>>

    merck millipore,默克密理博,506156,p38 MAP Kinase Inhibitor V - CAS 271576-77-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,506156,p38 MAP Kinase Inhibitor V - CAS 271576-77-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₀ClN₅271576-77-3
    描述
    概述 A cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1δ and p38α (IC50 = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC50 = 2.3, 10.5, 19.7, and 69.7 µM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 µM or higher. An excellent tool for studying p38-mediated responses both in cells in vitro and in animals in vivo.
    产品目录编号 506156
    品牌系列 Calbiochem®
    同义词 4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine, SC-409
    参考
    参考 Mbalaviele, G., et al. 2006. J. Pharm. Exp. Ther. 317, 1044.
    Liu, Y.H., et al. 2005. J. Card. Fail. 11, 74.
    Yu, J.J., et al. 2003. J. Immunol. 171, 6112.
    产品信息
    CAS号 271576-77-3
    具有ATP竞争性 Y
    形式 Light yellow solid
    Hill配方 C₁₉H₂₀ClN₅
    化学配方 C₁₉H₂₀ClN₅
    Molar Mass 353.9
    可逆 N
    结构配方图像
    生物信息
    主靶 p38 MAP Kinase
    主靶IC50 20 and 40 nM, against CK1δ and p38α, respectively
    纯度 ≥90% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,506156,p38 MAP Kinase Inhibitor V - CAS 271576-77-3 - Calbiochem

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