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品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, WB, ICC Sh Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5441 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Tropomyosin Antibody 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in PBS. 应用 应用 This Anti-Tropomyosin Antibody is validated for use in WB, IC, IH for the detection of Tropomyosin. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western Blot: 1:200-1:1,000. The antibody reacts with the ~29 kDa Tropomyosin protein on mouse brain cytosol. An additional band at ~52-55 kDa may be seen depending on sample and antibody concentration used. It is thought that this band may be a dimer.
Immunocytochemistry: 1:100-1:500
Immunohistochemistry: 1:100-1:500
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to the 9d exon from the alpha gene of tropomyosin. 宿主 Sheep 特异性 Recognizes Tropomyosin 1, 2, 3, 5a, 5b, 6. 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001018020.1
- NM_000366.5
- NM_001018004.1
- NM_001018005.1
- NM_001018006.1
- NM_001018007.1
- NM_001018008.1
Entrez基因汇总 This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. 基因符号 - TPM1
- CMH3
- Tropomyosin-1
- HTM-alpha
- Alpha-tropomyosin
- TMSA
- C15orf13
UniProt编号 - P09493
UniProt汇总 FUNCTION: SwissProt: P09493 # Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
SIZE: 284 amino acids; 32709 Da
SUBUNIT: Heterodimer of an alpha and a beta chain.
TISSUE SPECIFICITY: Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients.
DOMAIN: SwissProt: P09493 The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven- residues periodicity.
DISEASE: SwissProt: P09493 # Defects in TPM1 are the cause of familial hypertrophic cardiomyopathy type 3 (CMH3) [MIM:115196]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy [MIM:192600] is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
SIMILARITY: Belongs to the tropomyosin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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